Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Jul 13;16(7):e64452.
doi: 10.7759/cureus.64452. eCollection 2024 Jul.

Drug-Induced Angioedema Without Urticaria: A Case Report

Shrinivas R Raikar  1 , Sreeraj G  1 , Sneha Sneha  1 , Janarthanan R  1
Affiliations
Case Reports

Drug-Induced Angioedema Without Urticaria: A Case Report

Shrinivas R Raikar et al. Cureus. .

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for various conditions but are associated with numerous adverse drug reactions (ADRs). Understanding these ADRs is necessary to reduce morbidity and mortality. NSAID-induced angioedema, although rare, can be life-threatening and is often due to increased leukotriene production from COX pathway inhibition. Mast cells and basophil degranulation play vital roles in its pathogenesis. Prompt recognition and immediate cessation of the culprit drug, along with the administration of corticosteroids and antihistamines, are essential. Here, we report a case of angioedema caused by diclofenac administration, which needs prompt vigilance and a rapid therapeutic response.

Keywords: adverse drug reactions; angioedema; diclofenac; leukotrienes; non-steroidal anti-inflammatory drugs.

PubMed Disclaimer

Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Diclofenac-induced hypersensitivity reaction - angioedema
See this image and copyright information in PMC

References

    1. Drug-induced angioedema without urticaria: prevalence and clinical features. Leeyaphan C, Kulthanan K, Jongjarearnprasert K, Dhana N. J Eur Acad Dermatol Venereol. 2010;24:685–691. - PubMed
    1. Alfaro RA, Davis DD. StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2024. Diclofenac. - PubMed
    1. Diclofenac-induced urticarial angioedema: a case report. Rohini M, Reddy S, V P, Kumar S, L J. Asian J Pharm Clin Res. 2017;16:16.

Publication types

LinkOut - more resources