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Review
. 2024 Nov;173(3):470-480.
doi: 10.1111/imm.13843. Epub 2024 Aug 13.

The role and therapeutic strategies for tissue-resident memory T cells, central memory T cells, and effector memory T cells in psoriasis

Guoshu Deng #  1 , Yulin Zhang #  1 , Jiankun Song #  2 , Ying Zhang  2 , Qi Zheng  2 , Yue Luo  2 , Xiaoya Fei  2 , Yang Yang  2 , Le Kuai  1 , Bin Li  2   3 , Ying Luo  1   3
Affiliations
Review

The role and therapeutic strategies for tissue-resident memory T cells, central memory T cells, and effector memory T cells in psoriasis

Guoshu Deng et al. Immunology. 2024 Nov.

Abstract

Psoriasis is a skin disease that is inflammatory and persistent, causing a high rate of recurrence, poor quality of life, and significant socioeconomic burden. Its main pathological manifestations are abnormal activation and infiltration of T cells and excessive proliferation of keratinocytes (KCs). The great majority of patients with psoriasis will relapse after remission. It usually lasts a lifetime and necessitates long-term treatment strategies. During periods of activity and remission, one of the main cell types in psoriasis is memory T cells, which include tissue-resident memory T (TRM) cells, central memory T (TCM) cells, and effector memory T (TEM) cells. They work by releasing inflammatory factors, cytotoxic particles, or altering cell subpopulations, leading to increased inflammation or recurrence. This review summarizes the role of memory T cells in the pathology and treatment of psoriasis, with a view to potential novel therapies and therapeutic targets.

Keywords: TCM; TEM; TRM; psoriasis; recurrence.

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References

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