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. 2024;18(10-12):513-521.
doi: 10.1080/17520363.2024.2347199. Epub 2024 Aug 13.

Blood MALT1 reflects acute exacerbation risk and inflammation in elderly chronic obstructive pulmonary disease patients

Cui Liu  1 , Jinsong Zhu  1 , Lei Zhao  1 , Guanying Li  1 , Jiawei Sun  1 , Shengli Zhang  1 , Xijun Liang  1
Affiliations

Blood MALT1 reflects acute exacerbation risk and inflammation in elderly chronic obstructive pulmonary disease patients

Cui Liu et al. Biomark Med. 2024.

Abstract

Aim: This study intended to investigate the ability of blood MALT1 to estimate acute exacerbation risk in elderly chronic obstructive pulmonary disease (COPD) patients.Methods: Blood MALT1 was detected in 176 elderly COPD patients (aged more than 60 years).Results: MALT1 was elevated in patients with COPD acute exacerbation versus patients with stable COPD (p < 0.001). In patients with COPD acute exacerbation, MALT1 was negatively related to forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) (p = 0.024) and FEV1% predicted (p = 0.002), but positively linked with global initiative for chronic obstructive lung disease stage (p = 0.005).Conclusion: Blood MALT1 reflects increased acute exacerbation risk and inflammation in elderly COPD patients.

Keywords: MALT1; acute exacerbation; chronic obstructive pulmonary disease; disease severity; inflammation.

Plain language summary

[Box: see text].

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Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.

Figures

Figure 1.
Figure 1.
Comparison of MALT1 expression, TNF-α, IL-6, IL-8 and IL-17A between elderly COPD patients and HCs. MALT1 expression was increased in elderly COPD patients compared with HCs (A); MALT1 expression showed a good ability to discriminate elderly COPD patients from HCs (B); TNF-α (C), IL-6 (D), IL-8 (E) and IL-17A (F) were increased in elderly COPD patients compared with HCs. AUC: Area under the curve; CI: Confidence interval; COPD: Chronic obstructive pulmonary disease; HC: Healthy control.
Figure 2.
Figure 2.
Relationship of MALT1 expression with TNF-α, IL-6, IL-8 and IL-17A in elderly COPD patients. MALT1 expression was positively correlated with TNF-α (A), IL-6 (B), IL-8 (C) and IL-17A (D) in elderly COPD patients. COPD: Chronic obstructive pulmonary disease.
Figure 3.
Figure 3.
Comparison of MALT1 expression between patients with COPD acute exacerbation and patients with stable COPD. MALT1 expression was increased in patients with COPD acute exacerbation compared with patients with stable COPD (A); MALT1 expression showed am acceptable ability to discriminate patients with COPD acute exacerbation from patients with stable COPD (B). AUC: Area under the curve; CI: Confidence interval; COPD: Chronic obstructive pulmonary disease.
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