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. 2024 Nov 1;15(11):e00758.
doi: 10.14309/ctg.0000000000000758.

Evaluation of Chronic Pancreatitis Prognosis Score in an American Cohort

Soo Kyung Park  1 , Darwin L Conwell  2 , Phil A Hart  3 , Shuang Li  1 , Kimberly Stello  4 , Evan L Fogel  5 , William E Fisher  6 , Christopher E Forsmark  7 , Stephen J Pandol  8 , Walter G Park  9 , Mark Topazian  10 , Jose Serrano  11 , Santhi Swaroop Vege  10 , Stephen K Van Den Eeden  12 , Liang Li  1 , Dhiraj Yadav  4 , Jami L Saloman  4 ; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
Affiliations

Evaluation of Chronic Pancreatitis Prognosis Score in an American Cohort

Soo Kyung Park et al. Clin Transl Gastroenterol. .

Abstract

Introduction: Chronic Pancreatitis Prognosis Score (COPPS) was developed to discriminate disease severity and predict risk for future hospitalizations. In this cohort study, we evaluated if COPPS predicts the likelihood of hospitalization(s) in an American cohort.

Methods: The Chronic Pancreatitis, Diabetes, and Pancreatic Cancer consortium provided data and serum from subjects with chronic pancreatitis (N = 279). COPPS was calculated with baseline data and stratified by severity (low, moderate, and high). Primary endpoints included number and duration of hospitalizations during 12-month follow-up.

Results: The mean ± SD COPPS was 8.4 ± 1.6. COPPS correlated with all primary outcomes: hospitalizations for any reason (number: r = 0.15, P = 0.01; duration: r = 0.16, P = 0.01) and pancreas-related hospitalizations (number: r = 0.15, P = 0.02; duration: r = 0.13, P = 0.04). The severity distribution was 13.3% low, 66.0% moderate, and 20.8% high. 37.6% of subjects had ≥1 hospitalization(s) for any reason; 32.2% had ≥1 pancreas-related hospitalizations. All primary outcomes were significantly different between severity groups: hospitalizations for any reason (number, P = 0.004; duration, P = 0.007) and pancreas-related hospitalizations (number, P = 0.02; duration, P = 0.04). The prevalence of continued drinking at follow-up ( P = 0.04) was higher in the low and moderate groups. The prevalence of anxiety at enrollment ( P = 0.02) and follow-up ( P < 0.05) was higher in the moderate and high groups.

Discussion: Statistically, COPPS significantly correlated with hospitalization outcomes, but the correlations were weaker than in previous studies, which may be related to the outpatient nature of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies cohort and lower prevalence of high severity disease. Studies in other prospective cohorts are needed to understand the full utility of COPPS as a potential tool for clinical risk assessment and intervention.

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Conflict of interest statement

Guarantor of the article: Jami L. Saloman, PhD.

Specific author contributions: D.Y. and D.L.C. co-direct the PROCEED study. D.Y., D.L.C., and J.L.S. generated the concept for this study. J.L.S. initiated and coordinated the study. S.K.P. and J.L.S. drafted the initial manuscript. S.K.P., S.L., and L.L. analyzed the data. K.S. performed the CRP assay. P.A.H., E.L.F., W.E.F., C.E.F., S.J.P., W.G.P., M.T., S.S.V., and S.K.V. serve as PI for their respective centers on the PROCEED study. All authors gave input to and have approved the final manuscript and had final responsibility for the decision to submit for publication.

Financial support: This work was supported by the National Cancer Institute (NCI) and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under award numbers: R21DK122293 and K01DK120737 (J.L.S), U01DK108288 (S.S.V. and M.T), U01DK108300 (W.G.P), U01DK108306 (D.Y), U01DK108314 (S.J.P), U01DK108323 (E.L.F), U01DK108326 (W.E.F), U01DK108327 (P.A.H. and D.L.C), U01DK108332 (S.K.V), U01DK108320 (C.E.F), and U01DK108328 (S.K.P., L.L). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Potential competing interests: None to report.

Figures

Figure 1.
Figure 1.
Flowchart for identification of study population (Consolidated Standards of Reporting Trials diagram). COPPS, Chronic Pancreatitis Prognosis Score; CP, chronic pancreatitis; CRP, c-reactive protein; HbA1c, hemoglobin A1c; PDAC, pancreatic ductal adenocarcinoma; PROCEED, PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies.
Figure 2.
Figure 2.
Linear correlation between number of hospitalizations and total duration (d) of hospitalizations in patients with chronic pancreatitis during 12-month follow-up and COPPS score. Number of any hospitalizations (a), number of pancreas-related hospitalizations (b), total duration of any hospitalizations (c), and total duration of pancreas-related hospitalizations (d). Complete results of correlation analysis are presented in Supplementary Table 3, Supplementary Digital content 1 (http://links.lww.com/CTG/B183). COPPS, Chronic Pancreatitis Prognosis Score.
See this image and copyright information in PMC

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