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. 2024 Aug 13;111(4):848-852.
doi: 10.4269/ajtmh.24-0181. Print 2024 Oct 2.

Field Effectiveness of a Typhoid Conjugate Vaccine: The 2018 Navi Mumbai Pediatric TCV Campaign

Kashmira Date  1 , Christopher LeBoa  2 , Seth A Hoffman  2 , Pradeep Haldar  3 , Pauline Harvey  4 , Qian An  1 , Chenhua Zhang  1 , Vijay N Yewale  5 , Savita Daruwalla  6 , Dhanya Dharmapalan  5 , Jeetendra Gavhane  7 , Shrikrishna Joshi  8 , Rajesh Rai  9 , Varsha Rathod  10 , Keertana Shetty  11 , Divyalatha S Warrier  12 , Shalini Yadav  13 , Rahul Shimpi  4 , Niniya Jayaprasad  4 , Lily Horng  2 , Kirsten Fagerli  1 , Priyanka Borhade  4 , Debjit Chakraborty  14 , Arun Katkar  4 , Abhishek Kunwar  4 , Jason R Andrews  2 , Sunil Bahl  15 , Pankaj Bhatnagar  4 , Shanta Dutta  14 , Stephen P Luby  2
Affiliations

Field Effectiveness of a Typhoid Conjugate Vaccine: The 2018 Navi Mumbai Pediatric TCV Campaign

Kashmira Date et al. Am J Trop Med Hyg. .

Abstract

Typbar-TCV®, a typhoid conjugate vaccine (TCV), was prequalified by the World Health Organization in 2017. We evaluated its effectiveness in a mass vaccination program targeting children 9 months to 14 years in Navi Mumbai, India, from September 2018 to July 2020. We compared laboratory-confirmed typhoid cases from six clinical sites with age-matched community controls. Of 38 cases, three (8.6%) received TCV through the campaign, compared with 53 (37%) of 140 controls. The adjusted odds ratio of typhoid fever among vaccinated children was 0.16 (95% CI: 0.05-0.55), equivalent to a vaccine effectiveness of 83.7% (95% CI: 45.0-95.3). Vaccine effectiveness of Typbar-TCV in this large public sector vaccine introduction was similar to prior randomized controlled trials, providing reassurance to policymakers that TCV effectiveness is robust in a large-scale implementation.

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Conflict of interest statement

Disclosure: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position, policies, or views of the U.S. Centers for Disease Control and Prevention or the World Health Organization.

Figures

Figure 1.
Figure 1.
Flow chart of study design. TCV = typhoid conjugate vaccine.
See this image and copyright information in PMC

References

    1. GBD 2017 Typhoid and Paratyphoid Collaborators , 2019. The global burden of typhoid and paratyphoid fevers: A systematic analysis for the global burden of disease study 2017. Lancet Infect Dis 19: 369–381. - PMC - PubMed
    1. Mogasale VV, Ramani E, Mogasale V, Park JY, Wierzba TF, 2018. Estimating typhoid fever risk associated with lack of access to safe water: A systematic literature review. J Environ Public Health 2018: 9589208. - PMC - PubMed
    1. World Health Organization , 2019. Typhoid vaccines: WHO position paper, March 2018—Recommendations. Vaccine 37: 214–216. - PubMed
    1. Tseng KK, Joshi J, Shrivastava S, Klein E, 2020. Estimating the cost of interventions to improve water, sanitation and hygiene in healthcare facilities across India. BMJ Glob Health 5: e003045. - PMC - PubMed
    1. Kim C, Goucher GR, Tadesse BT, Lee W, Abbas K, Kim JH, 2023. Associations of water, sanitation, and hygiene with typhoid fever in case-control studies: A systematic review and meta-analysis. BMC Infect Dis 23: 562. - PMC - PubMed

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