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Review
. 2024 Aug 13;19(1):107.
doi: 10.1186/s13014-024-02485-8.

Clinical implications of the serum platelet-to-lymphocyte ratio in the modern radiation oncology era: research update and literature review

Dong Soo Lee  1
Affiliations
Review

Clinical implications of the serum platelet-to-lymphocyte ratio in the modern radiation oncology era: research update and literature review

Dong Soo Lee. Radiat Oncol. .

Abstract

Radiation therapy (RT) continues to be the primary approach for treating cancer, and numerous cancer biomarkers associated with oncological outcomes have been investigated in the context of RT. The serum platelet-to-lymphocyte ratio (PLR) is one of the emerging landmark biomarker in the oncologic field. Mounting evidence indicates that an elevated serum PLR may function as a marker of unfavorable tumor characteristics, adverse treatment outcomes and treatment-related toxicities among individuals undergoing RT. However, the findings of these investigations have revealed a few disparities among researchers, highlighting the need for further meticulously planned studies to draw conclusive results. This article provides a comprehensive literature review and in-depth discussion regarding the clinical implications of the serum PLR in the modern RT era.

Keywords: Biomarker; Cancer; Platelet-to-lymphocyte ratio; Radiation therapy.

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Conflict of interest statement

None/DSL contributed to the conception and design of the study, the methodology, surveyed the literature data, and drafted the manuscript.

Figures

Fig. 1
Fig. 1
A summary of the clinical implications of the increased PLR
See this image and copyright information in PMC

References

    1. Baskar R, Lee KA, Yeo R, Yeoh KW. Cancer and radiation therapy: current advances and future directions. Int J Med Sci. 2012;9:193–9. 10.7150/ijms.3635 - DOI - PMC - PubMed
    1. Baskar R, Dai J, Wenlong N, Yeo R, Yeoh KW. Biological response of cancer cells to radiation treatment. Front Mol Biosci. 2014;1:24. 10.3389/fmolb.2014.00024 - DOI - PMC - PubMed
    1. Chetty IJ, et al. Technology for Innovation in Radiation Oncology. Int J Radiat Oncol Biol Phys. 2015;93:485–92. 10.1016/j.ijrobp.2015.07.007 - DOI - PMC - PubMed
    1. Feain IJ, Court L, Palta JR, Beddar S, Keall P. Innovations in Radiotherapy Technology. Clin Oncol (R Coll Radiol (G B)). 2017;29:120–8.10.1016/j.clon.2016.10.009 - DOI - PubMed
    1. Jaffray DA. Image-guided radiotherapy: from current concept to future perspectives. Nat Rev Clin Oncol. 2012;9:688–99. 10.1038/nrclinonc.2012.194 - DOI - PubMed

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