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Randomized Controlled Trial
. 2024 Oct;37(5):1186-1196.
doi: 10.1111/jhn.13350. Epub 2024 Aug 13.

Assessing metabolic flexibility response to a multifibre diet: a randomised-controlled trial

Adrien Aubin  1   2   3 , Hugo Hornero-Ramirez  1   2 , Harimalala Ranaivo  1   2 , Chantal Simon  1   2 , Laurie Van Den Berghe  1   2 , Nathalie Feugier Favier  1   2 , Isabelle Dussous  4 , Loïc Roger  4 , Martine Laville  1   2 , Christel Béra-Maillet  5 , Joël Doré  5   6 , Cyrielle Caussy  1   2   3 , Julie-Anne Nazare  1   2
Affiliations
Randomized Controlled Trial

Assessing metabolic flexibility response to a multifibre diet: a randomised-controlled trial

Adrien Aubin et al. J Hum Nutr Diet. 2024 Oct.

Abstract

Introduction: Metabolic flexibility (MetF), defined as the ability to switch between fat and glucose oxidation, is increasingly recognised as a critical marker for assessing responses to dietary interventions. Previously, we showed that the consumption of multifibre bread improved insulin sensitivity and reduced low-density lipoprotein cholesterol (LDLc) levels in overweight and obese individuals. As a secondary objective, we aimed to explore whether our intervention could also improve MetF.

Methods: In this study, 39 subjects at cardiometabolic risk participated in a double-blind, randomised, crossover trial lasting 8 weeks, repeated twice. During each phase, participants consumed either 150 g of standard bread daily or bread enriched with a mixture of seven dietary fibres. MetF response was assessed using a mixed-meal tolerance test (MMTT), analysing changes in respiratory quotient (∆RQ) measured using indirect calorimetry.

Results: Although there were no significant differences in ∆RQ changes induced by dietary fibre between the two diets, these changes were positively correlated with postprandial triglyceride excursion (∆TG) at baseline. Subgroup analysis of baseline fasting and postprandial plasma metabolites was conducted to characterise MetF responders. These responders exhibited higher baseline fasting LDLc levels and greater post-MMTT ∆TG.

Conclusion: In conclusion, although dietary fibres did not directly impact MetF in this study, our findings highlight potential determinants of MetF response, warranting further investigation in dedicated future interventions.

Keywords: cardiometabolic profile; cardiometabolic risk; dietary fibre; dietary intervention; metabolic flexibility; mixed‐meal test.

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References

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