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. 2024 Jul 30:12:1423657.
doi: 10.3389/fped.2024.1423657. eCollection 2024.

Patterns and unique features of infantile cholestasis among Arabs

Abdulrahman Al-Hussaini  1   2   3 , Sami Alrashidi  1 , Deema H Hafez  4 , Yasir S Alkhalifah  5 , Bashaer Otayn  6 , Majid Alrasheed  7 , Sumayah Al Mufarreh  8 , Sultan AlKasim  9
Affiliations

Patterns and unique features of infantile cholestasis among Arabs

Abdulrahman Al-Hussaini et al. Front Pediatr. .

Abstract

Background: Most of the literature on infantile cholestasis (IC) originated from Caucasian and Asian populations. The differential diagnosis of IC is very broad, and identification of etiology is challenging to clinicians because the list includes many entities with overlapping clinical, biochemical, and histological features. Thus, a structured, stepwise diagnostic approach is required to help early recognition and prompt evaluation and management of treatable causes of cholestasis.

Objective: (1) To determine the differential diagnosis of IC among Saudi population and (2) to evaluate the usefulness of a diagnostic algorithm that has been tailored by the authors to the local practice.

Methods: All infants with onset of cholestasis before 12 months of age (2007 and 2020) were identified and included if they underwent extensive work up to exclude infectious, structural, metabolic, endocrine, infiltrative, and familial causes.

Results: Our diagnostic pathway allowed a definite diagnosis in 373 of the included 533 cases; 160 (30%) were labelled as "idiopathic neonatal hepatitis" (INH) [i.e., overall 70% detection rate]. However, when considering the cases that underwent extensive investigations including advanced gene testing (415 of the 533), the yield of the diagnostic algorithm was 90% (373/415). Familial cholestasis group was the most common in 20% (107/533), and biliary atresia and neonatal-onset Dubin Johnson syndrome contributed to 6% each. The genetic/hereditary causes of cholestasis contributed to 58% of the diagnosed cases (217/373). No single case of alpha-1 antitrypsin deficiency was diagnosed. Forty-nine infants with cholestasis presented with liver failure (9%).

Conclusion: Our study highlights several unique features and causes of IC among Arabs which could have a great impact on the differential diagnosis process and the choice of laboratory tests used in the clinical setting.

Keywords: Saudi Arabia; idiopathic neonatal hepatitis; liver disease; next-generation sequence; whole exome sequence.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the diagnostic protocol for infantile cholestasis adopted in our center. The “red flags” are written in bolded red color. The places in the algorithm where we have incorporated different types of gene tests are highlighted by yellow color.
Figure 2
Figure 2
Regional distribution of the founder variants.
Figure 3
Figure 3
Time trend of the use of liver biopsy and gene testing in the work up of infantile cholestasis.
See this image and copyright information in PMC

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