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. 2024 Jul 30:15:1393526.
doi: 10.3389/fphar.2024.1393526. eCollection 2024.

A scientometrics analysis and visualization of refractory gastroesophageal reflux disease

Nan Zhang  1 , Ming Han  1 , Qin-Wei Zheng  1 , Meng-Yuan Zhang  1 , Wen-Lan Zhi  1 , Jing-Jing Li  1 , Lin-Xuan Cui  1 , Jin-Li Tian  1 , Yi Wang  1 , Sheng-Quan Fang  1
Affiliations

A scientometrics analysis and visualization of refractory gastroesophageal reflux disease

Nan Zhang et al. Front Pharmacol. .

Abstract

Background: Refractory gastroesophageal reflux disease (refractory GERD) is a heterogeneous disease characterized by unresponsiveness or poor efficacy to proton-pump inhibitors (PPIs). This chronic disorder substantially weakens patients' mental wellbeing and quality of life, increasing the financial burden on society. Multiple articles have been reported in this area. However, literature involving scientometric analysis of refractory GERD is absent. Therefore, it is necessary to understand the evolution of research themes and the main hotspots of refractory GERD through bibliometric methods.

Methods: All documents related to refractory GERD based on the WOS Core Collection from January 2000 to November 2023 were selected for analysis. Citespace V 6.1 R6, VOSviewer V 1.6.20, and Scimago Graphica V 1.0.38 were used to perform bibliometric analysis.

Results: We collected a total of 241 research articles from 36 countries and 322 institutions, contributed by over 1,000 authors. Over the last 20 years, the number of articles in this field has increased year by year, and since 2011, the number of publications has increased dramatically, with 85.89% of the papers. These countries are led by the United States and Japan. GUT had the highest number of citations and DIGESTION had the highest number of publications. Research on standardized diagnosis and management, mechanisms, novel monitoring methods, and innovative drugs and procedures for refractory GERD are the main topics and hotspots in this field. This study also found that neuroimmune interaction is closely related to refractory GERD, which may be a new direction for future mechanism research.

Conclusion: Our study is the first bibliometric analysis of the global literature on refractory GERD. This research provides valuable insights for researchers, enabling them to quickly understand the research frontier and hot topics of this field.

Keywords: Citespace; refractory GERD; research hotspots; scientometrics analysis; visualization.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Flowchart of the literature-screening process and research framework.
FIGURE 2
FIGURE 2
Trends in the growth of the publications and numbers of cited articles worldwide from 2000 to 2023.
FIGURE 3
FIGURE 3
Cooperation map of countries/regions in refractory GERD.
FIGURE 4
FIGURE 4
Cooperation map of authors in refractory GERD.
FIGURE 5
FIGURE 5
References with the strongest citation bursts.
FIGURE 6
FIGURE 6
Map of keyword clustering in refractory GERD.
FIGURE 7
FIGURE 7
Timeline view and evolutionary path in refractory GERD.
See this image and copyright information in PMC

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