Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul 30:15:1424207.
doi: 10.3389/fendo.2024.1424207. eCollection 2024.

Plasma aldosterone concentrations elevation in hypertensive patients: the dual impact on hyperuricemia and gout

Shuaiwei Song #  1   2 , Xintian Cai #  1   2 , Junli Hu  1   2 , Qing Zhu  1   2 , Di Shen  1   2 , Huimin Ma  1   2 , Yingying Zhang  1   2 , Rui Ma  1   2 , Pan Zhou  1   2 , Wenbo Yang  1   2 , Jing Hong  1   2 , Delian Zhang  1   2 , Nanfang Li  1   2
Affiliations

Plasma aldosterone concentrations elevation in hypertensive patients: the dual impact on hyperuricemia and gout

Shuaiwei Song et al. Front Endocrinol (Lausanne). .

Abstract

Background: Prior research has highlighted the association between uric acid (UA) and the activation of the renin-angiotensin-aldosterone system (RAAS). However, the specific relationship between aldosterone, the RAAS's end product, and UA-related diseases remains poorly understood. This study aims to clarify the impact of aldosterone on the development and progression of hyperuricemia and gout in hypertensive patients.

Methods: Our study involved 34534 hypertensive participants, assessing plasma aldosterone concentration (PAC)'s role in UA-related diseases, mainly hyperuricemia and gout. We applied multiple logistic regression to investigate the impact of PAC and used restricted cubic splines (RCS) for examining the dose-response relationship between PAC and these diseases. To gain deeper insights, we conducted threshold analyses, further clarifying the nature of this relationship. Finally, we undertook subgroup analyses to evaluate PAC's effects across diverse conditions and among different subgroups.

Results: Multivariate logistic regression analysis revealed a significant correlation between the occurrence of hyperuricemia and gout and the elevation of PAC levels. Compared to the first quartile (Q1) group, groups Q2, Q3, and Q4 all exhibited a significantly increased risk of occurrence. Moreover, the conducted RCS analysis demonstrated a significant nonlinear dose-response relationship, especially when PAC was greater than 14 ng/dL, with a further increased risk of hyperuricemia and gout. Finally, comprehensive subgroup analyses consistently reinforced these findings.

Conclusion: This study demonstrates a close association between elevated PAC levels and the development of UA-related diseases, namely hyperuricemia and gout, in hypertensive patients. Further prospective studies are warranted to confirm and validate this relationship.

Keywords: gout; hypertension; hyperuricemia; plasma aldosterone concentration; uric acid.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of participant selection.
Figure 2
Figure 2
Prevalence of hyperuricemia according to the PAC quartile.
Figure 3
Figure 3
Prevalence of gout according to the PAC quartile.
Figure 4
Figure 4
Dose-response association between PAC and risk of hyperuricemia.
Figure 5
Figure 5
Dose-response association between PAC and risk of gout.
See this image and copyright information in PMC

References

    1. Wen S, Arakawa H, Tamai I. Uric acid in health and disease: From physiological functions to pathogenic mechanisms. Pharmacol Ther. (2024) 256:108615. doi: 10.1016/j.pharmthera.2024.108615 - DOI - PubMed
    1. Stamp L, Dalbeth N. Screening for hyperuricaemia and gout: a perspective and research agenda. Nat Rev Rheumatol. (2014) 10:752–6. doi: 10.1038/nrrheum.2014.139 - DOI - PubMed
    1. Ponticelli C, Podestà MA, Moroni G. Hyperuricemia as a trigger of immune response in hypertension and chronic kidney disease. Kidney Int. (2020) 98:1149–59. doi: 10.1016/j.kint.2020.05.056 - DOI - PubMed
    1. Bjornstad P, Laffel L, Lynch J, El Ghormli L, Weinstock RS, Tollefsen SE, et al. Elevated serum uric acid is associated with greater risk for hypertension and diabetic kidney diseases in obese adolescents with type 2 diabetes: an observational analysis from the treatment options for type 2 diabetes in adolescents and youth (TODAY) study. Diabetes Care. (2019) 42:1120–8. doi: 10.2337/dc18-2147 - DOI - PMC - PubMed
    1. Johnson RJ, Bakris GL, Borghi C, Chonchol MB, Feldman D, Lanaspa MA, et al. Hyperuricemia, acute and chronic kidney disease, hypertension, and cardiovascular disease: report of a scientific workshop organized by the national kidney foundation. Am J Kidney diseases: Off J Natl Kidney Foundation. (2018) 71:851–65. doi: 10.1053/j.ajkd.2017.12.009 - DOI - PMC - PubMed

LinkOut - more resources