Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov;31(11):1269-1277.
doi: 10.1111/iju.15553. Epub 2024 Aug 14.

Can the Briganti 2019 nomogram be modified to predict lymph node metastasis risk in patients with prostate cancer detected with in-bore biopsy?

Serdar Madendere  1 , Mert Kılıç  1 , Bengi Gürses  2 , Metin Vural  3 , Ayşe Armutlu  4 , İbrahim Kulaç  4 , Kayhan Tarım  5 , Barış Esen  5 , İbrahim Can Aykanat  5 , Mert Veznikli  6 , Abdullah Erdem Canda  5   7 , Derya Balbay  1   5 , Dilek Ertoy Baydar  4 , Yakup Kordan  5 , Tarık Esen  1   5
Affiliations

Can the Briganti 2019 nomogram be modified to predict lymph node metastasis risk in patients with prostate cancer detected with in-bore biopsy?

Serdar Madendere et al. Int J Urol. 2024 Nov.

Abstract

Objectives: We aimed to modify the Briganti 2019 nomogram and to test whether it is valid for patients who were diagnosed with prostate cancer through in-bore prostate biopsies.

Methods: Data for 204 patients with positive multiparametric prostate MRI and prostate cancer identified either by mpMRI-cognitive/software fusion or in-bore biopsy and who underwent robot-assisted radical prostatectomy and extended pelvic lymph node dissection between 2012 and 2023 were retrospectively analyzed. The Briganti 2019 nomogram was applied to the mpMRI-cognitive/software fusion biopsy group (142 patients) in the original form, and then, two modifications were tested for the targeted component. Original and modified scores were compared. These modifications were adapted for the in-bore biopsy group (62 patients). The final histopathologic stage was regarded as the gold standard.

Results: Nodal metastases were identified in 18/142 (12.6%) of mpMRI-cognitive/software fusion biopsy patients and 8/62 (12.9%) of the in-bore biopsy patients. In the mpMRI-cognitive/software fusion biopsy group, tumor size/core size (%) of targeted biopsy cores and positive core percentage on systematic biopsy were significant parameters for lymph node metastasis based on univariate logistic regression analyses (p < 0.05). With the modifications of these parameters for the in-bore biopsy group, V1 modification of the Briganti 2019 nomogram provided 100% sensitivity and 31.5% specificity (AUC:0.627), while V2 modification provided 75% sensitivity and 46.3% specificity (AUC:0.645).

Conclusions: Briganti 2019 nomogram may be modified by utilizing tumor size/core size (%) for targeted biopsy cores instead of positive core percentage on systematic biopsy or by not taking both parameters into consideration to detect node metastasis risk of patients diagnosed with in-bore biopsies.

Keywords: lymph node metastasis; nomograms; prostate cancer; targeted biopsy.

PubMed Disclaimer

References

REFERENCES

    1. Kilic M, Madendere S, Vural M, Koseoglu E, Balbay MD, Esen T. The role of the size and number of index lesion in the diagnosis of clinically significant prostate cancer in patients with PI‐RADS 4 lesions who underwent in‐bore MRI‐guided prostate biopsy. World J Urol. 2023;41:449–454.
    1. Özkan A, Köseoğlu E, Kılıç M, Baydar DE, Sağlıcan Y, Balbay MD, et al. The impact of visible tumor (PI‐RADS ≥3) on upgrading and adverse pathology at radical prostatectomy in low risk prostate cancer patients: a biopsy core based analysis. Clin Genitourin Cancer. 2022;20:e61–e67.
    1. Brembilla G, Dell'Oglio P, Stabile A, Ambrosi A, Cristel G, Brunetti L, et al. Preoperative multiparametric MRI of the prostate for the prediction of lymph node metastases in prostate cancer patients treated with extended pelvic lymph node dissection. Eur Radiol. 2018;28:1969–1976.
    1. Gandaglia G, Ploussard G, Valerio M, Mattei A, Fiori C, Fossati N, et al. A novel nomogram to identify candidates for extended pelvic lymph node dissection among patients with clinically localized prostate cancer diagnosed with magnetic resonance imaging‐targeted and systematic biopsies. Eur Urol. 2019;75:506–514.
    1. Miah S, Hosking‐Jervis F, Connor MJ, Eldred‐Evans D, Shah TT, Arya M, et al. A multicentre analysis of the detection of clinically significant prostate cancer following transperineal image‐fusion targeted and nontargeted systematic prostate biopsy in men at risk. Eur Urol Oncol. 2020;3:262–269.

MeSH terms

LinkOut - more resources