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. 2025 Feb 1;120(2):478-481.
doi: 10.14309/ajg.0000000000003031. Epub 2024 Aug 14.

US National Estimates of Contemporary Mortality Rates in Patients With Ulcerative Colitis Undergoing Colectomy

Newaz Shubidito Ahmed  1 , Satchel Krawchuk  2 , Katherine A Buhler  3 , Virginia Solitano  4   5   6 , Vipul Jairath  4   7 , Abdel Aziz Shaheen  3   8 , Cynthia H Seow  3 , Kerri L Novak  3 , Richard J M Ingram  3 , Cathy Lu  3 , Paulo G Kotze  9 , Gilaad G Kaplan  3   8 , Remo Panaccione  3 , Christopher Ma  3   8
Affiliations

US National Estimates of Contemporary Mortality Rates in Patients With Ulcerative Colitis Undergoing Colectomy

Newaz Shubidito Ahmed et al. Am J Gastroenterol. .

Abstract

Introduction: Despite a growing armamentarium of medical therapies for ulcerative colitis, colectomy remains an important therapeutic option. To better inform shared decision-making about surgery, we estimated the contemporary risk of mortality after colectomy.

Methods: Mortality rates were estimated using the National Inpatient Sample (2016-2020). Factors associated with postcolectomy death were evaluated in multivariable regression.

Results: Postcolectomy mortality occurred in 1.2% (95% CI: 0.8%, 1.9%) of hospitalizations. Comorbidity burden, emergent laparotomy, and delays to surgery >5 days after admission were associated with mortality.

Discussion: Colectomy may be associated with mortality; however, this risk is heterogeneous based on patient- and procedural-related factors.

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References

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    1. Parragi L, Fournier N, Zeitz J, et al. Colectomy rates in ulcerative colitis are low and decreasing: 10-year follow-up data from the Swiss IBD cohort study. J Crohns Colitis 2018;12(7):811–8.
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