Wriggly woes: Helminths stirring up T cell trouble

Carlos M Pondevida¹, Atishay Jay¹, Golnaz Vahedi²

Affiliations

¹ Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.
² Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: vahedi@pennmedicine.upenn.edu.

PMID: 39142272
DOI: 10.1016/j.immuni.2024.07.014

Free article

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Wriggly woes: Helminths stirring up T cell trouble

Carlos M Pondevida et al. Immunity. 2024.

Free article

. 2024 Aug 13;57(8):1726-1728.

doi: 10.1016/j.immuni.2024.07.014.

Authors

Carlos M Pondevida¹, Atishay Jay¹, Golnaz Vahedi²

Affiliations

¹ Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, USA.
² Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: vahedi@pennmedicine.upenn.edu.

PMID: 39142272
DOI: 10.1016/j.immuni.2024.07.014

Abstract

Understanding determinants of immune response variation is central to developing treatment options. Even et al. show that naive CD4⁺ T cell transcriptional heterogeneity is altered by helminth infection leading to impaired immune responses independent of commensals.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

The amalgam of naive CD4⁺ T cell transcriptional states is reconfigured by helminth infection to dampen the amplitude of the immune response.
Even Z, Meli AP, Tyagi A, Vidyarthi A, Briggs N, de Kouchkovsky DA, Kong Y, Wang Y, Waizman DA, Rice TA, De Kumar B, Wang X, Palm NW, Craft J, Basu MK, Ghosh S, Rothlin CV. Even Z, et al. Immunity. 2024 Aug 13;57(8):1893-1907.e6. doi: 10.1016/j.immuni.2024.07.006. Epub 2024 Aug 2. Immunity. 2024. PMID: 39096910 Free PMC article.

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Wriggly woes: Helminths stirring up T cell trouble

Affiliations

Wriggly woes: Helminths stirring up T cell trouble

Authors

Affiliations

Abstract

Conflict of interest statement

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Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Research Materials