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Comment
. 2024 Aug 13;57(8):1731-1733.
doi: 10.1016/j.immuni.2024.07.013.

Macrophages dig into the obesity paradox in cancer

Christopher S Nabel  1 , Florian Gourgue  2 , Matthew G Vander Heiden  3
Affiliations
Free article
Comment

Macrophages dig into the obesity paradox in cancer

Christopher S Nabel et al. Immunity. .
Free article

Abstract

Response to immune checkpoint blockade is increased in obesity-related cancers, but the mechanisms remain unclear. In a recent issue of Nature, Bader et al. report that obesity in mice induces macrophage PD-1 upregulation to promote tumor growth while potentiating immunotherapy responses.

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Conflict of interest statement

Declaration of interests C.S.N. discloses royalty income from Cambridge Epigenetix and stock ownership in Opko Health. M.G.V.H. is a member of the scientific advisory board for iTeos Therapeutics, Agios Pharmaceuticals, Sage Therapeutics, Pretzel Therapeutics, Lime Therapeutics, Faeth Therapeutics, MPM Capital, DROIA Ventures, and Auron Therapeutics.

Comment on

  • Obesity induces PD-1 on macrophages to suppress anti-tumour immunity.
    Bader JE, Wolf MM, Lupica-Tondo GL, Madden MZ, Reinfeld BI, Arner EN, Hathaway ES, Steiner KK, Needle GA, Hatem Z, Landis MD, Faneuff EE, Blackman A, Wolf EM, Cottam MA, Ye X, Bates ME, Smart K, Wang W, Pinheiro LV, Christofides A, Smith D, Boussiotis VA, Haake SM, Beckermann KE, Wellen KE, Reinhart-King CA, Serezani CH, Lee CH, Aubrey C, Chen H, Rathmell WK, Hasty AH, Rathmell JC. Bader JE, et al. Nature. 2024 Jun;630(8018):968-975. doi: 10.1038/s41586-024-07529-3. Epub 2024 Jun 12. Nature. 2024. PMID: 38867043 Free PMC article.

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