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. 2024 Aug 14;22(1):103.
doi: 10.1186/s12958-024-01273-z.

Molecular regulation of DNA damage and repair in female infertility: a systematic review

Xiuhua Xu #  1   2 , Ziwei Wang #  1 , Luyi Lv  1 , Ci Liu  1 , Lili Wang  1 , Ya-Nan Sun  1 , Zhiming Zhao  1 , Baojun Shi  1 , Qian Li  3 , Gui-Min Hao  4
Affiliations

Molecular regulation of DNA damage and repair in female infertility: a systematic review

Xiuhua Xu et al. Reprod Biol Endocrinol. .

Abstract

DNA damage is a key factor affecting gametogenesis and embryo development. The integrity and stability of DNA are fundamental to a woman's successful conception, embryonic development, pregnancy and the production of healthy offspring. Aging, reactive oxygen species, radiation therapy, and chemotherapy often induce oocyte DNA damage, diminished ovarian reserve, and infertility in women. With the increase of infertility population, there is an increasing need to study the relationship between infertility related diseases and DNA damage and repair. Researchers have tried various methods to reduce DNA damage in oocytes and enhance their DNA repair capabilities in an attempt to protect oocytes. In this review, we summarize recent advances in the DNA damage response mechanisms in infertility diseases such as PCOS, endometriosis, diminished ovarian reserve and hydrosalpinx, which has important implications for fertility preservation.

Keywords: DNA damage; DNA damage response; DNA repair; Infertility; Oocyte; ROS.

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Conflict of interest statement

The authors declare no competing interests.

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