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Review
. 2024 Jul 14;3(5):100185.
doi: 10.1016/j.cellin.2024.100185. eCollection 2024 Oct.

The monkeypox virus-host interplays

Xue-Mei Yi  1 , Ya-Li Lei  1 , Mi Li  1 , Li Zhong  2 , Shu Li  1
Affiliations
Review

The monkeypox virus-host interplays

Xue-Mei Yi et al. Cell Insight. .

Abstract

Monkeypox virus (MPXV) is a DNA virus belonging to the Orthopoxvirus genus within the Poxviridae family which can cause a zoonotic infection. The unexpected non-endemic outbreak of mpox in 2022 is considered as a new global threat. It is imperative to take proactive measures, including enhancing our understanding of MPXV's biology and pathogenesis, and developing novel antiviral strategies. The host immune responses play critical roles in defensing against MPXV infection while the virus has also evolved multiple strategies for immune escape. This review summarizes the biological features, antiviral immunity, immune evasion mechanisms, pathogenicity, and prevention strategies for MPXV.

Keywords: Antiviral immunity; Immune evasion; Monkeypox virus; Pathogenicity.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
MPXV Genome and structure (A) The MPXV genome has a large, conserved central region encoding essential factors. Flanking this core are two variable regions with identical but opposite sequences at their ends, known as ITRs. (B) The MPXV is made up of five main parts: a double-concave dumbbell-shaped core, lipoprotein membrane, lateral bodies, surface tubules and its genomic DNA.
Fig. 2
Fig. 2
Immune evasion by MPXV MPXV encodes multiple immunomodulators that disrupt host antiviral responses through diverse strategies, including preventing production of IFNs, blocking IFN-induced signaling pathways and activation of NF-κB, inhibition of immune cell activation, regulation of apoptosis and inflammasomes. See text for details.
See this image and copyright information in PMC

References

    1. Adamo S., Gao Y., Sekine T., Mily A., Wu J., Storgard E., Westergren V., Filen F., Treutiger C.J., Sandberg J.K., Sallberg M., Bergman P., Llewellyn-Lacey S., Ljunggren H.G., Price D.A., Ekstrom A.M., Sette A., Grifoni A., Buggert M. Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox. Cell Host Microbe. 2023;31(6):928–936 e4. - PMC - PubMed
    1. Adler H., Gould S., Hine P., Snell L.B., Wong W., Houlihan C.F., Osborne J.C., Rampling T., Beadsworth M.B., Duncan C.J., Dunning J., Fletcher T.E., Hunter E.R., Jacobs M., Khoo S.H., Newsholme W., Porter D., Porter R.J., Ratcliffe L., Network, N.H.S.E.H.C.I.D. Clinical features and management of human monkeypox: A retrospective observational study in the UK. The Lancet Infectious Diseases. 2022;22(8):1153–1162. - PMC - PubMed
    1. Al-Musa A., Chou J., LaBere B. The resurgence of a neglected orthopoxvirus: Immunologic and clinical aspects of monkeypox virus infections over the past six decades. Clin Immunol. 2022;243 - PMC - PubMed
    1. Albarnaz J.D., Ren H., Torres A.A., Shmeleva E.V., Melo C.A., Bannister A.J., Brember M.P., Chung B.Y., Smith G.L. Molecular mimicry of NF-kappaB by vaccinia virus protein enables selective inhibition of antiviral responses. Nat Microbiol. 2022;7(1):154–168. - PMC - PubMed
    1. Alcami A., Smith G.L. Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity. Journal of Virology. 1995;69(8):4633–4639. - PMC - PubMed

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