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Randomized Controlled Trial
. 2024 Aug 1;7(8):e2429621.
doi: 10.1001/jamanetworkopen.2024.29621.

Risk of Self-Reported Penicillin Allergy Despite Removal of Penicillin Allergy Label: Secondary Analysis of the PALACE Randomized Clinical Trial

Ana Maria Copaescu  1   2 , Sara Vogrin  3 , Abby Douglas  4 , Nicholas A Turner  5 , Elizabeth J Phillips  6 , Natasha E Holmes  2 , Jason A Trubiano  2
Affiliations
Randomized Controlled Trial

Risk of Self-Reported Penicillin Allergy Despite Removal of Penicillin Allergy Label: Secondary Analysis of the PALACE Randomized Clinical Trial

Ana Maria Copaescu et al. JAMA Netw Open. .
No abstract available

Plain language summary

This secondary analysis of adult patients in the Penicillin Allergy Clinical Decision Rule (PALACE) Study investigates the risk of self-reported penicillin allergy despite removal of penicillin allergy label.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Douglas reported personal fees from Gilead Sciences (honoraria paid to institution) outside the submitted work. Dr Turner reported grants from the Centers for Disease Control and Prevention, research contract from Purio Labs, and research contract from PDI outside the submitted work. Dr Phillips reported grants from the National Institutes of Health and the National Health and Medical Research Council (NHMRC), and personal fees from UpToDate, Janssen, Biocryst, Verve, Esperion, AstraZeneca, Novavax, and Regeneron outside the submitted work. No other disclosures were reported.

References

    1. Copaescu AM, Vogrin S, James F, et al. . Efficacy of a clinical decision rule to enable direct oral challenge in patients with low-risk penicillin allergy: the PALACE randomized clinical trial. JAMA Intern Med. 2023;183(9):944-952. doi:10.1001/jamainternmed.2023.2986 - DOI - PMC - PubMed
    1. Trubiano JA, Vogrin S, Chua KYL, et al. . Development and validation of a penicillin allergy clinical decision rule. JAMA Intern Med. 2020;180(5):745-752. doi:10.1001/jamainternmed.2020.0403 - DOI - PMC - PubMed
    1. Copaescu AM, James F, Vogrin S, et al. . Use of a penicillin allergy clinical decision rule to enable direct oral penicillin provocation: an international multicentre randomised control trial in an adult population (PALACE): study protocol. BMJ Open. 2022;12(8):e063784. doi:10.1136/bmjopen-2022-063784 - DOI - PMC - PubMed
    1. Pinto T, Li J, Boyle T, Zaragoza R, Fernando SL. Follow-up of penicillin allergy labels 1 year after successful penicillin delabeling. Ann Allergy Asthma Immunol. 2023;130(1):80-83.e3. doi:10.1016/j.anai.2022.09.012 - DOI - PubMed
    1. Lutfeali S, DiLoreto FF, Alvarez KS, et al. . Maintaining penicillin allergy delabeling: a quality improvement initiative. J Allergy Clin Immunol Pract. 2021;9(5):2104-2106.e2. doi:10.1016/j.jaip.2021.01.005 - DOI - PubMed

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