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. 2024 Oct 1;32(5):329-338.
doi: 10.1097/MOO.0000000000000996. Epub 2024 Jul 26.

Newborn congenital cytomegalovirus screening and hearing outcomes: a systematic review of current literature

Sarah A Pollick  1 , Yusra Mansour  2 , Megan H Pesch  1
Affiliations

Newborn congenital cytomegalovirus screening and hearing outcomes: a systematic review of current literature

Sarah A Pollick et al. Curr Opin Otolaryngol Head Neck Surg. .

Abstract

Purpose of review: The purpose of this review is to summarize the very recent literature surrounding hearing outcomes of children with congenital cytomegalovirus (cCMV) detected through systematic screening programs.

Recent findings: There are several different approaches to cCMV screening including forms of targeted vs. universal screening of newborns as well as maternally-derived prenatal testing. However, many studies fail to document hearing-related outcomes both in the newborn period and further into childhood when late-onset sensorineural hearing loss (SNHL) can occur. This systematic review included studies of neonates screened for cCMV reporting hearing outcomes for at least one point in time. Hearing targeted screening appeared the most widely reported for detection of unilateral and bilateral SNHL in those with cCMV. A few studies examined these clinical findings in relation to antiviral treatment.

Summary: Congenital CMV is an important and common cause of childhood hearing loss. Newborn screening programs may expand opportunities for early diagnosis and treatment of the infection and its sequelae.

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Conflict of interest statement

CONFLICTS OF INTEREST MHP serves on the board of directors of the National CMV Foundation, is consultant for MedScape/Web MD, Diasorin and Moderna.

Figures

Figure 1.
Figure 1.
PRISMA flow diagram *Consider, if feasible to do so, reporting the number of records identified from each database or register searched (rather than the total number across all databases/registers). **If automation tools were used, indicate how many records were excluded by a human and how many were excluded by automation tools. From: Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71. doi: 10.1136/bmj.n71. For more information, visit: http://www.prisma-statement.org/
See this image and copyright information in PMC

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      *Landmark study following children with asymptomatic cCMV into adulthood

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