Visualizing synaptic pruning in the mammalian brain

Rachana Deven Somaiya^{1

2}, Marla B Feller^{1

2}

Affiliations

¹ Department of Neuroscience, University of California, Berkeley, CA 94720, USA.
² Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.

Comment

Rachana Deven Somaiya et al. Science. 2024.

. 2024 Aug 16;385(6710):711-712.

doi: 10.1126/science.adr3322. Epub 2024 Aug 15.

Rachana Deven Somaiya^{1

2}, Marla B Feller^{1

2}

¹ Department of Neuroscience, University of California, Berkeley, CA 94720, USA.
² Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.

Abstract

Patterns of spontaneous neuronal activity instruct the refinement of developing brain circuits.

Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity.
Matsumoto N, Barson D, Liang L, Crair MC. Matsumoto N, et al. Science. 2024 Aug 16;385(6710):eadh7814. doi: 10.1126/science.adh7814. Epub 2024 Aug 16. Science. 2024. PMID: 39146415 Free PMC article.