Review
doi: 10.1016/S2666-5247(24)00134-4.
Epub 2024 Aug 13.
WHO global research priorities for antimicrobial resistance in human health
Silvia Bertagnolio
1
, Zlatina Dobreva
2
, Chad M Centner
2
, Ioana Diana Olaru
3
, Daniele Donà
4
, Stefano Burzo
2
, Benedikt D Huttner
2
, Antoine Chaillon
2
, Nebiat Gebreselassie
5
, Teodora Wi
6
, Mateusz Hasso-Agopsowicz
7
, Benedetta Allegranzi
8
, Hatim Sati
2
, Verica Ivanovska
2
, Kavita U Kothari
9
, Hanan H Balkhy
2
, Alessandro Cassini
10
, Raph L Hamers
11
, Kitty Van Weezenbeek
2
; WHO Research Agenda for AMR in Human Health Collaborators
Collaborators,
Affiliations
Collaborators
-
WHO Research Agenda for AMR in Human Health Collaborators:
David Aanensen 12 , Alexandre Alanio 13 , Ana Alastruey-Izquierdo 14 , Tinsae Alemayehu 15 , Majdi Al-Hasan 16 , Karel Allegaert 17 , Amal Saif Al-Maani 18 , Jameela Al-Salman 19 , Abeer Nizar Alshukairi 20 , Afreenish Amir 21 , Tanya Applegate 22 , George F Araj 23 , Marlen Arce Villalobos 24 , Christine Årdal 25 , Diane Ashiru-Oredope 26 , Elizabeth A Ashley 27 , François-Xavier Babin 28 , Laura H Bachmann 29 , Till Bachmann 30 , Kate Susan Baker 31 , Manica Balasegaram 32 , Colleen Bamford 33 , Fernando Baquero 34 , Laura Isabel Barcelona 35 , Quique Bassat 36 , Matteo Bassetti 37 , Sulagna Basu 38 , Justin Beardsley 39 , Grey Benoit Vásquez 40 , James A Berkley 41 , Anuj K Bhatnagar 42 , Julia Bielicki 43 , Julie Bines 44 , Felix Bongomin 45 , Robert A Bonomo 46 , John S Bradley 47 , Catriona Bradshaw 48 , Ana Brett 49 , Adrian Brink 50 , Colin Brown 26 , Jeremy Brown 51 , Kirsty Buising 52 , Carolee Carson 53 , Anna Cristina Carvalho 54 , Elio Castagnola 55 , Marco Cavaleri 56 , Michele Cecchini 57 , Chishala Chabala 58 , Richard E Chaisson 59 , Arunaloke Chakrabarti 60 , Clare Chandler 61 , Sujith John Chandy 62 , Esmita Charani 63 , Lisa Chen 64 , Francesca Chiara 65 , Anuradha Chowdhary 66 , Arlene Chua 67 , Pem Chuki 68 , Doo Ryeon Chun 69 , Gavin Churchyard 70 , Daniela Cirillo 71 , Lauren Clack 72 , Susan E Coffin 73 , Jennifer Cohn 32 , Michelle Cole 74 , John Conly 75 , Ben Cooper 12 , Alejandra Corso 76 , Sara E Cosgrove 77 , Helen Cox 78 , Charles L Daley 79 , Saffiatou Darboe 80 , Tom Darton 81 , Gerry Davies 82 , Viviana de Egea 83 , Amela Dedeić-Ljubović 84 , Miranda Deeves 85 , Claudia Denkinger 86 , Jo-Anne R Dillon 87 , Angela Dramowski 88 , Brian Eley 89 , Susanna Maria Roberta Esposito 90 , Sabiha Y Essack 91 , Helmia Farida 92 , Joveria Farooqi 93 , Nicholas Feasey 94 , Cecilia Ferreyra 95 , Helen Fifer 26 , Heather Finlayson 88 , Mike Frick 96 , Ana Cristina Gales 97 , Luisa Galli 98 , Sumanth Gandra 99 , Jeffrey S Gerber 100 , Christian Giske 101 , Bruce Gordon 85 , Nelesh Govender 102 , Nathalie Guessennd 103 , Ibrehima Guindo 104 , Elmira Gurbanova 105 , Amanda Gwee 106 , Ferry Hagen 107 , Stephan Harbarth 108 , John Haze 109 , Jutta Heim 110 , Rene Hendriksen 111 , Robert Simon Heyderman 112 , Kathryn Elizabeth Holt 61 , Martin Hönigl 113 , Edward W Hook 114 , William Hope 82 , Heidi Hopkins 61 , Gwenda Hughes 61 , Ghada Ismail 115 , Mohammad Iqbal Issack 116 , Jan Jacobs 117 , Dušan Jasovský 118 , Fyeza Jehan 119 , Antonieta Jimenez Pearson 120 , Makoto Jones 121 , Mohan P Joshi 122 , Arti Kapil 123 , Samuel Kariuki 124 , Abhilasha Karkey 125 , Gregory L Kearns 126 , Karen Helena Keddy 127 , Nina Khanna 128 , Akiko Kitamura 129 , Kaija-Leena Kolho 130 , Dimitrios P Kontoyiannis 131 , Anita Kotwani 132 , Roman S Kozlov 133 , Katharina Kranzer 61 , Ranmini Kularatne 134 , Monica M Lahra 135 , Bradley J Langford 136 , Rafael Laniado-Laborin 137 , Joakim Larsson 138 , Cornelia Lass-Flörl 139 , Kirsty Le Doare 140 , Hyukmin Lee 141 , Fernanda Lessa 29 , Anna S Levin 142 , Direk Limmathurotsakul 143 , Nilton Lincopan 144 , Andrea Lo Vecchio 145 , Rakesh Lodha 146 , Mark Loeb 147 , Yves Longtin 148 , David Chien Lye 149 , Asif Mujtaba Mahmud 150 , Célia Manaia 151 , Lenore Manderson 152 , Ivana Mareković 153 , Kalisvar Marimuthu 154 , Irene Martin 155 , Tapfumanei Mashe 156 , Zeng Mei 157 , Jacques F Meis 158 , Flávio Augusto Lyra Tavares De Melo 159 , Marc Mendelson 50 , Angelica Espinosa Miranda 160 , David Moore 161 , Chantal Morel 162 , Nyambura Moremi 163 , Maria Luisa Moro 164 , Francis Moussy 85 , Stephen Mshana 165 , Arno Mueller 85 , Francis J Ndow 166 , Mark Nicol 167 , Andrew Nunn 168 , Stephen Obaro 169 , Christina W Obiero 170 , Iruka N Okeke 171 , Uduak Okomo 172 , Tochi J Okwor 173 , Rita Oladele 174 , Sylvia Omulo 175 , Pascale Ondoa 176 , Juana Medarda Ortellado de Canese 177 , Luis Ostrosky-Zeichner 178 , Maria Clara Padoveze 179 , Madhukar Pai 180 , Benjamin Park 29 , Julian Parkhill 181 , Christopher M Parry 182 , Rosanna Peeling 61 , Luísa Maria Sobreira Vieira Peixe 183 , Olga Perovic 184 , Melinda M Pettigrew 185 , Nicola Principi 186 , Céline Pulcini 187 , Nelly Puspandari 188 , Timothy Rawson 63 , Denasha Lavanya Reddy 152 , Kessendri Reddy 152 , Paulo Redner 189 , Juan Luis Rodríguez Tudela 190 , Jesús Rodríguez-Baño 191 , Susan Rogers Van Katwyk 192 , Emmanuel Roilides 193 , Christine Rollier 194 , Leslie Rollock 195 , Jean-Baptiste Ronat 196 , Etienne Ruppe 197 , Manish Sadarangani 198 , David Salisbury 199 , Mounerou Salou 200 , Luc Hervé Samison 201 , Maurizio Sanguinetti 202 , Massimo Sartelli 203 , Natalie Schellack 204 , Jeroen Schouten 205 , Mitchell J Schwaber 206 , Jeremiah Seni 207 , Abiola Senok 208 , William M Shafer 209 , Sadia Shakoor 210 , Donald Sheppard 53 , Jong-Hee Shin 211 , Sonia Sia 212 , Dawn Sievert 29 , Ishwar Singh 213 , Rupak Singla 214 , Robert Leo Skov 215 , Olusegun O Soge 216 , Rosanne Sprute 217 , Arjun Srinivasan 218 , Subasree Srinivasan 29 , Arnfinn Sundsfjord 219 , Evelina Tacconelli 220 , Sabira Tahseen 221 , Viroj Tangcharoensathien 222 , Thomas Tängdén 223 , Karin Thursky 224 , Guy Thwaites 225 , Renata Tigulini de Souza Peral 226 , Deborah Tong 85 , Hafsah Deepa Tootla 227 , Constantinos Tsioutis 228 , Katy M Turner 229 , Paul Turner 230 , Shaheed Vally Omar 231 , Wendy Wj van de Sande 232 , Susan van den Hof 233 , Rogier van Doorn 234 , Balaji Veeraraghavan 235 , Paul Verweij 236 , Retno Wahyuningsih 237 , Hui Wang 238 , Adilia Warris 239 , Hillard Weinstock 240 , Evelyn Wesangula 241 , David Whiley 218 , Peter J White 242 , Phoebe Williams 243 , Yonghong Xiao 244 , Martin Yagui Moscoso 245 , Hsu Li Yang 246 , Sachiyo Yoshida 85 , Yunsong Yu 247 , Dorota Żabicka 248 , Matteo Zignol 85 , Igor Rudan 249
Affiliations
- 1 Antimicrobial Resistance Division, WHO, Geneva, Switzerland. Electronic address: bertagnolios@who.int.
- 2 Antimicrobial Resistance Division, WHO, Geneva, Switzerland.
- 3 Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK; Institute of Medical Microbiology, University of Münster, Münster, Germany.
- 4 Division of Paediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, Padua, Italy.
- 5 Global Tuberculosis Programme, WHO, Geneva, Switzerland.
- 6 Global HIV, Hepatitis and STI Programme, WHO, Geneva, Switzerland.
- 7 Department of Immunization, Vaccines & Biologicals, WHO, Geneva, Switzerland.
- 8 Department of Integrated Health Services, WHO, Geneva, Switzerland.
- 9 Library and Digital Information Networks, WHO, Kobe, Japan.
- 10 Public Health Department, Canton of Vaud, Lausanne, Switzerland; Infectious Diseases Service, Lausanne University Hospital, Lausanne, Switzerland.
- 11 Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
- 12 University of Oxford, United Kingdom.
- 13 Institut Pasteur, Université Paris Cité, National Reference Center for Invasive Mycoses and Antifungals, Translational Mycology research group, Mycology Department, Paris, France; Laboratoire de parasitologie-mycologie, AP-HP, Hôpital Saint-Louis, Paris, France.
- 14 Instituto de Salud Carlos III, Spain.
- 15 St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia and American medical center, Addis Ababa, Ethiopia.
- 16 University of South Carolina School of Medicine; Prisma Health-Midlands, Columbia, South Carolina, United States of America.
- 17 KU Leuven, Belgium.
- 18 Ministry of Health, Oman.
- 19 Salmaniya Medical Complex, Bahrain.
- 20 Alfaisal University in Riyadh, Saudi Arabia; Previously King Faisal Specialist Hospital and Research Center in Jeddah, Saudi Arabia.
- 21 National Institute of Health, Pakistan.
- 22 Kirby Institute, UNSW Sydney, Australia.
- 23 American University of Beirut - Medical Center, Lebanon.
- 24 Ministerio de Salud, Costa Rica.
- 25 Norwegian Institute of Public Health, Norway.
- 26 UK Health Security Agency, United Kingdom.
- 27 Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Mahosot Hospital, Vientiane, Lao PDR; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
- 28 Fondation Mérieux, France.
- 29 Centers for Disease Control and Prevention, United States of America.
- 30 Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh.
- 31 Department of Genetics, University of Cambridge, Downing Place, Cambridge, United Kingdom.
- 32 Global Antibiotic R&D Partnership (GARDP).
- 33 Pathcare, South Africa.
- 34 Ramón y Cajal Institute for Health Research, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Spain.
- 35 Ministerio de Salud de la Nación, Argentina.
- 36 Barcelona Institute for Global Health (ISGlobal), Spain.
- 37 University of Genoa, Italy.
- 38 ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.
- 39 University of Sydney, Australia.
- 40 Dirección de Epidemiología, Ministerio de Salud Pública y Asistencia Social, Dominican Republic.
- 41 KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya; Centre for Tropical Medicine & Global Health, University of Oxford, UK.
- 42 Rajan Babu Institute for Pulmonary Medicine and Tuberculosis, India.
- 43 St George's University of London, United Kingdom; University of Basel Children's Hospital, Switzerland.
- 44 The University of Melbourne; Murdoch Children's Research Institute; Department of Gastroenterology and Clinical Nutrition, The Royal Children's Hospital.
- 45 Gulu University, Uganda.
- 46 Cleveland VA Medical Center, Case Western Reserve University, United States of America.
- 47 University of California, San Diego, School of Medicine.
- 48 Monash University, Australia.
- 49 Clínica Universitária de Pediatria, Faculdade de Medicina, Universidade de Coimbra, Portugal.
- 50 University of Cape Town, South Africa.
- 51 University College London, United Kingdom.
- 52 Victorian Infectious Diseases Unit, Royal Melbourne Hospital, Australia; Department of Infectious Diseases, University of Melbourne, Australia.
- 53 Public Health Agency of Canada, Canada.
- 54 Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
- 55 IRCCS Istituto Giannina Gaslini, Italy.
- 56 European Medicines Agency, Netherlands.
- 57 Organisation for Economic Co-operation and Development (OECD), France.
- 58 University of Zambia, Zambia.
- 59 Johns Hopkins University School of Medicine; Johns Hopkins Center for Tuberculosis Research; Johns Hopkins Center for AIDS Research.
- 60 Doodhadhari Burfani Hospital and Research Institute, Haridwar, India.
- 61 London School of Hygiene and Tropical Medicine, United Kingdom.
- 62 Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, India.
- 63 Imperial College London, United Kingdom.
- 64 UCSF Curry International Tuberculosis Center, United States of America.
- 65 Center for Infectious Disease Research and Policy, United States of America.
- 66 Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi; National Reference Laboratory For Antimicrobial Resistance in Fungal Pathogens, Medical Mycology Unit, Department of Microbiology, Patel Chest Institute, University of Delhi, Delhi, India.
- 67 Médecins Sans Frontières, Switzerland.
- 68 Jigme Dorji Wangchuck National Referral Hospital, Bhutan.
- 69 Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
- 70 The Aurum Institute, Parktown, South Africa; Department of Medicine, Vanderbilt University, Nashville, TN, US.
- 71 San Raffaele Scientific Institute, Italy.
- 72 University of Zurich, Institute for Implementation Science in Health Care, Zurich, Switzerland.
- 73 Children's Hospital of Philadelphia /University of Pennsylvania School of Medicine, United States of America.
- 74 STI Reference Laboratory, UKHSA, London, UK.
- 75 University of Calgary and Alberta Health Services, Canada.
- 76 Servicio Antimicrobianos - INEI ANLIS Dr Carlos G. Malbrán, Argentina.
- 77 Johns Hopkins University School of Medicine, United States of America.
- 78 Institute of Infectious Diseases and Molecular Medicine, Division of Medical Microbiology, University of Cape Town.
- 79 National Jewish Center, United States of America.
- 80 MRC Unit The Gambia at the LSHTM.
- 81 University of Sheffield, United Kingdom.
- 82 University of Liverpool, United Kingdom.
- 83 Ministry of Health, Paraguay.
- 84 Clinical Center of the University Sarajevo, Bosnia and Herzegovina.
- 85 World Health Organization, Geneva, Switzerland.
- 86 Division of Infectious Disease and Tropical Medicine, German Center for Infection Research (DZIF) partner site, University Hospital Heidelberg, Germany.
- 87 University of Saskatchewan, Canada.
- 88 Stellenbosch University, South Africa.
- 89 Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
- 90 University of Parma, Italy.
- 91 Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
- 92 Universitas Diponegoro, Indonesia.
- 93 Aga Khan University, Karachi, Pakistan.
- 94 School of Medicine, University of St Andrews, St Andrews, UK and Liverpool School of Tropical Medicine, Liverpool, UK.
- 95 FIND, Switzerland.
- 96 Treatment Action Group, United States of America.
- 97 Universidade Federal de São Paulo, Brazil.
- 98 Department of Health Science, University of Florence and Infectious Disease Unit, Meyer Children's Hospital, IRCCS, Florence, Italy.
- 99 Washington University School of Medicine in St. Louis, United States of America.
- 100 Children's Hospital of Philadelphia, United States of America.
- 101 Karolinska Institute, Sweden.
- 102 National Institute for Communicable Diseases, South Africa.
- 103 Institut Pasteur de Côte d'Ivoire, Ivory Coast.
- 104 National Institute of Public Health, Bamako-Mali, Mali.
- 105 Tartu University Clinic, Estonia.
- 106 Department of General Medicine, Royal Children's Hospital, Antimicrobials Group, Murdoch Children's Research Institute, Department of Paediatrics, The University of Melbourne.
- 107 Westerdijk Fungal Biodiversity Institute (WI-KNAW), Netherlands.
- 108 University Hospital Geneva (HUG), Switzerland.
- 109 Ministry of Health, St Vincent & the Grenadines.
- 110 Helmholtz Centre for Infection Research, Switzerland.
- 111 Technical University of Denmark, Denmark.
- 112 University College London (UCL), United Kingdom.
- 113 Medical University of Graz, Austria.
- 114 University of Alabama at Birmingham, United States of America.
- 115 Supreme Council for University Hospitals, Egypt.
- 116 Central Health Laboratory, Ministry of Health and Wellness, Mauritius.
- 117 Institute of Tropical Medicine, Antwerp, Belgium.
- 118 Médecins Sans Frontières Access Campaign, Switzerland.
- 119 The Aga Khan University, Pakistan.
- 120 National Reference Center of Bacteriology - INCIENSA, Costa Rica.
- 121 University of Utah, United States of America.
- 122 Medicines, Technologies, and Pharmaceutical Services (MTaPS) Program, Management Sciences for Health, United States of America.
- 123 North DMC Medical College and Hindu Rao Hospital, India.
- 124 Director Eastern Africa, Drugs for Neglected Diseases Initiative, Nairobi, Kenya.
- 125 Oxford University Clinical Research Unit Nepal, Nepal.
- 126 Professor of Pediatrics and Medical Education, The Burnett School of Medicine at Texas Christian University, Fort Worth, TX, United States of America.
- 127 Independent Consultant, South Africa.
- 128 University Hospital Basel, Switzerland.
- 129 Health, Nutrition and Population Global Practice, World Bank Group, United States of America.
- 130 Children´s Hospital, University of Helsinki and HUS, Helsinki, Finland.
- 131 Division of Internal Medicine, Houston, TX, United States of America.
- 132 Ex-Director professor, Department of Pharmacology, V. P. Chest Institute, University of Delhi, India.
- 133 Smolensk State Medical University, Russia.
- 134 Labtests Auckland, New Zealand.
- 135 WHO Collaborating Centre for ST and AMR, NSWHP Microbiology, The Prince of Wales Hospital, NSW, Australia.
- 136 Public Health Ontario, Canada.
- 137 Hospital General Tijuana, ISESALUD de Baja California, Mexico.
- 138 University of Gothenburg, Sweden.
- 139 Institute of Hygiene and Medical Microbiology European Excellence Center of Medical Mycology (ECMM), Medical University of Innsbruck, Innsbruck, Germany.
- 140 St. George's University of London, United Kingdom; Makerere University, Kampala, Uganda.
- 141 Severance Hospital, Yonsei University Medical College, Republic of Korea.
- 142 Universidade de São Paulo, Brazil.
- 143 Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
- 144 Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Brazil.
- 145 University of Naples Federico II, Italy.
- 146 All India Institute of Medical Sciences, India.
- 147 McMaster University, Canada.
- 148 Jewish General Hospital, Montreal, Canada.
- 149 National Centre for Infectious Diseases; Tan Tock Seng Hospital; Yong Loo Lin School of Medicine; Lee Kong Chian School of Medicine, Singapore.
- 150 Asgar Ali Hospital, Dhaka; Bangladesh Lung Foundation; Formerly at Institute of Epidemiology, Disease Control and Research (IEDCR), Mahakhali, Dhaka, Bangladesh.
- 151 Universidade Católica Portuguesa, Portugal.
- 152 University of the Witwatersrand, South Africa.
- 153 University Hospital Centre Zagreb, Department of Clinical Microbiology, Infection Prevention and Control, Zagreb, Croatia.
- 154 Tan Tock Seng, Hospital and National Centre for Infectious Diseases, Singapore.
- 155 National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
- 156 WHO, Ministry of Health and Child Care, Zimbabwe.
- 157 Children's Hospital of Fudan University, National Children's Medical Center, China.
- 158 University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn- Cologne-Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany.
- 159 Governo do Estado da Paraíba, Brazil.
- 160 Ministério da Saúde, Brazil.
- 161 Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa; South African Medical Research Council Vaccine and Infectious Diseases Analytics (VIDA) Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
- 162 University Hospital Bonn, Institute for Hygiene & Public Health, Germany.
- 163 National Public Health Laboratory, Tanzania.
- 164 Regional Health and Social Agency, Emilia Romagna Region, Italy.
- 165 Catholic University of Health and Allied Sciences, Tanzania.
- 166 Skin and GU Medicine Clinic, Harare, Zimbabwe.
- 167 University of Western Australia, Australia.
- 168 MRC Clinical Trials Unit at University College London, United Kingdom.
- 169 University of Nebraska Medical Center, United States of America.
- 170 Kenya Medical Research Insistute - Wellcome Trust Research Programme, Kenya.
- 171 University of Ibadan, Nigeria.
- 172 MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Gambia.
- 173 Nigeria Centre for Disease Control and Prevention, Nigeria.
- 174 College of Medicine, University of Lagos, Nigeria.
- 175 Washington State University, United States of America.
- 176 African Society for Laboratory Medicine (ASLM), Ethiopia.
- 177 Universidad Nacional de Asunción, Paraguay.
- 178 University of Texas Health Science Center at Houston, United States of America.
- 179 School of Nursing, University of São Paulo, Brazil.
- 180 McGill University, Canada.
- 181 University of Cambridge, United Kingdom.
- 182 Liverpool School of Tropical Medicine, United Kingdom.
- 183 Faculdade de Farmácia, Universidade do Porto, Portugal.
- 184 National Institute for Communicable Diseases a division of NHLS, South Africa.
- 185 Yale School of Public Health, United States of America.
- 186 University of Milan, Italy.
- 187 Université de Lorraine et CHRU Nancy, APEMAC et Centre régional en antibiothérapie du Grand Est AntibioEst, Nancy, France.
- 188 Health Policy Agency, Ministry of Health Indonesia, Indonesia.
- 189 FIOCRUZ, Brazil.
- 190 Global Action for Fungal Infections, United Kingdom.
- 191 Unidad Clínica de Enfermedades Infecciosas y Microbiología, Instituto de Biomedicina de Sevilla (IBiS)/CSIC, Hospital Universitario Virgen Macarena; Departamento de Medicina, Universidad de Sevilla, Seville, Spain. CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.
- 192 Global Strategy Lab, Canada.
- 193 Infectious Diseases Unit, 3rd Department Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, and Hippokration General Hospital, Thessaloniki, Greece.
- 194 University of Surrey, United Kingdom.
- 195 Ministry of Health and Wellness, Barbados.
- 196 IQLS, France.
- 197 Université de Paris, France.
- 198 University of British Columbia, Canada.
- 199 Programme for Global Health, Chatham House, London, United Kingdom.
- 200 Université de Lomé, Togo.
- 201 Centre d'infectiologie Charles Mérieux, University of Antananarivo, Madagascar.
- 202 Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy.
- 203 Department of Surgery, Macerata Hospital, Italy.
- 204 University of Pretoria, South Africa.
- 205 Radboud University, Netherlands.
- 206 National Center for Infection Control, Israel Ministry of Health, Israel.
- 207 Catholic University of Health and Allied Sciences (CUHAS), Mwanza, Tanzania.
- 208 College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates; School of Dentistry, Cardiff University, Cardiff, United Kingdom.
- 209 Emory University School of Medicine, United States of America.
- 210 Aga Khan University, Pakistan.
- 211 Chonnam National University Medical School, Republic of Korea.
- 212 Research Institute for Tropical Medicine, Philippines.
- 213 Antimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom; Antimicrobial Drug Discovery, Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool, United Kingdom.
- 214 National Institute of Tuberculosis and Respiratory diseases, New Delhi, India.
- 215 International Centre for Antimicrobial Resistance Solutions (ICARS).
- 216 University of Washington, Seattle, United States of America.
- 217 Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany.
- 218 University of Queensland, Australia.
- 219 UiT The Arctic University of Norway, Norway.
- 220 University of Verona, Italy.
- 221 National Tuberculosis Control Program, Pakistan.
- 222 International Health Policy Program, Ministry of Public Health, Thailand.
- 223 Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
- 224 University of Melbourne, Australia.
- 225 University of Oxford, Vietnam.
- 226 Ministry of Health, Brazil.
- 227 National Health Laboratory Services, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
- 228 European University Cyprus, Nicosia, Cyprus.
- 229 Aquarius Population Health, United Kingdom.
- 230 Cambodia-Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia; and Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.
- 231 National Institute for Communicable Diseases, a division of the National Health Laboratory Service, South Africa.
- 232 Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Netherlands.
- 233 National Institute for Public Health and the Environment, Netherlands.
- 234 Ha Noi Oxford University Clinical Research Unit, University of Oxford, United Kingdom.
- 235 Christian Medical College, India.
- 236 Radboudumc - CWZ Center of Expertise for Mycology; Center for Infectious Disease Research, Diagnostics and Laboratory Surveillance, the Netherlands.
- 237 Department of Parasitology, Universitas Indonesia, Faculty of Medicine, Jakarta, Indonesia; Department of Parasitology, Universitas Kristen Indonesia, Faculty of Medicine, Jakarta, Indonesia.
- 238 Peking University People's Hospital, Beijing, China.
- 239 MRC Centre for Medical Mycology, University of Exeter, United Kingdom.
- 240 No institutional affiliation, United States of America.
- 241 East Central and Southern Africa Health Community, Arusha, Tanzania.
- 242 Imperial College London, United Kingdom; United Kingdom Health Security Agency, United Kingdom.
- 243 University of Sydney / Sydney Children's Hospital Network, Australia.
- 244 Zhejiang University, China.
- 245 Instituto Nacional de Salud, Peru, and Universidad Nacional Mayor de San Marcos, Peru.
- 246 National University of Singapore, Singapore.
- 247 Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China.
- 248 National Medicines Institute, Warsaw, Poland.
- 249 The University of Edinburgh, United Kingdom.
- PMID: 39146948
- PMCID: PMC11543637
- DOI: 10.1016/S2666-5247(24)00134-4
Item in Clipboard
Review
WHO global research priorities for antimicrobial resistance in human health
Silvia Bertagnolio et al.
Lancet Microbe.
2024 Nov.
Display options
Format
doi: 10.1016/S2666-5247(24)00134-4.
Epub 2024 Aug 13.
Authors
Silvia Bertagnolio
1
, Zlatina Dobreva
2
, Chad M Centner
2
, Ioana Diana Olaru
3
, Daniele Donà
4
, Stefano Burzo
2
, Benedikt D Huttner
2
, Antoine Chaillon
2
, Nebiat Gebreselassie
5
, Teodora Wi
6
, Mateusz Hasso-Agopsowicz
7
, Benedetta Allegranzi
8
, Hatim Sati
2
, Verica Ivanovska
2
, Kavita U Kothari
9
, Hanan H Balkhy
2
, Alessandro Cassini
10
, Raph L Hamers
11
, Kitty Van Weezenbeek
2
; WHO Research Agenda for AMR in Human Health Collaborators
Collaborators
-
WHO Research Agenda for AMR in Human Health Collaborators:
David Aanensen 12 , Alexandre Alanio 13 , Ana Alastruey-Izquierdo 14 , Tinsae Alemayehu 15 , Majdi Al-Hasan 16 , Karel Allegaert 17 , Amal Saif Al-Maani 18 , Jameela Al-Salman 19 , Abeer Nizar Alshukairi 20 , Afreenish Amir 21 , Tanya Applegate 22 , George F Araj 23 , Marlen Arce Villalobos 24 , Christine Årdal 25 , Diane Ashiru-Oredope 26 , Elizabeth A Ashley 27 , François-Xavier Babin 28 , Laura H Bachmann 29 , Till Bachmann 30 , Kate Susan Baker 31 , Manica Balasegaram 32 , Colleen Bamford 33 , Fernando Baquero 34 , Laura Isabel Barcelona 35 , Quique Bassat 36 , Matteo Bassetti 37 , Sulagna Basu 38 , Justin Beardsley 39 , Grey Benoit Vásquez 40 , James A Berkley 41 , Anuj K Bhatnagar 42 , Julia Bielicki 43 , Julie Bines 44 , Felix Bongomin 45 , Robert A Bonomo 46 , John S Bradley 47 , Catriona Bradshaw 48 , Ana Brett 49 , Adrian Brink 50 , Colin Brown 26 , Jeremy Brown 51 , Kirsty Buising 52 , Carolee Carson 53 , Anna Cristina Carvalho 54 , Elio Castagnola 55 , Marco Cavaleri 56 , Michele Cecchini 57 , Chishala Chabala 58 , Richard E Chaisson 59 , Arunaloke Chakrabarti 60 , Clare Chandler 61 , Sujith John Chandy 62 , Esmita Charani 63 , Lisa Chen 64 , Francesca Chiara 65 , Anuradha Chowdhary 66 , Arlene Chua 67 , Pem Chuki 68 , Doo Ryeon Chun 69 , Gavin Churchyard 70 , Daniela Cirillo 71 , Lauren Clack 72 , Susan E Coffin 73 , Jennifer Cohn 32 , Michelle Cole 74 , John Conly 75 , Ben Cooper 12 , Alejandra Corso 76 , Sara E Cosgrove 77 , Helen Cox 78 , Charles L Daley 79 , Saffiatou Darboe 80 , Tom Darton 81 , Gerry Davies 82 , Viviana de Egea 83 , Amela Dedeić-Ljubović 84 , Miranda Deeves 85 , Claudia Denkinger 86 , Jo-Anne R Dillon 87 , Angela Dramowski 88 , Brian Eley 89 , Susanna Maria Roberta Esposito 90 , Sabiha Y Essack 91 , Helmia Farida 92 , Joveria Farooqi 93 , Nicholas Feasey 94 , Cecilia Ferreyra 95 , Helen Fifer 26 , Heather Finlayson 88 , Mike Frick 96 , Ana Cristina Gales 97 , Luisa Galli 98 , Sumanth Gandra 99 , Jeffrey S Gerber 100 , Christian Giske 101 , Bruce Gordon 85 , Nelesh Govender 102 , Nathalie Guessennd 103 , Ibrehima Guindo 104 , Elmira Gurbanova 105 , Amanda Gwee 106 , Ferry Hagen 107 , Stephan Harbarth 108 , John Haze 109 , Jutta Heim 110 , Rene Hendriksen 111 , Robert Simon Heyderman 112 , Kathryn Elizabeth Holt 61 , Martin Hönigl 113 , Edward W Hook 114 , William Hope 82 , Heidi Hopkins 61 , Gwenda Hughes 61 , Ghada Ismail 115 , Mohammad Iqbal Issack 116 , Jan Jacobs 117 , Dušan Jasovský 118 , Fyeza Jehan 119 , Antonieta Jimenez Pearson 120 , Makoto Jones 121 , Mohan P Joshi 122 , Arti Kapil 123 , Samuel Kariuki 124 , Abhilasha Karkey 125 , Gregory L Kearns 126 , Karen Helena Keddy 127 , Nina Khanna 128 , Akiko Kitamura 129 , Kaija-Leena Kolho 130 , Dimitrios P Kontoyiannis 131 , Anita Kotwani 132 , Roman S Kozlov 133 , Katharina Kranzer 61 , Ranmini Kularatne 134 , Monica M Lahra 135 , Bradley J Langford 136 , Rafael Laniado-Laborin 137 , Joakim Larsson 138 , Cornelia Lass-Flörl 139 , Kirsty Le Doare 140 , Hyukmin Lee 141 , Fernanda Lessa 29 , Anna S Levin 142 , Direk Limmathurotsakul 143 , Nilton Lincopan 144 , Andrea Lo Vecchio 145 , Rakesh Lodha 146 , Mark Loeb 147 , Yves Longtin 148 , David Chien Lye 149 , Asif Mujtaba Mahmud 150 , Célia Manaia 151 , Lenore Manderson 152 , Ivana Mareković 153 , Kalisvar Marimuthu 154 , Irene Martin 155 , Tapfumanei Mashe 156 , Zeng Mei 157 , Jacques F Meis 158 , Flávio Augusto Lyra Tavares De Melo 159 , Marc Mendelson 50 , Angelica Espinosa Miranda 160 , David Moore 161 , Chantal Morel 162 , Nyambura Moremi 163 , Maria Luisa Moro 164 , Francis Moussy 85 , Stephen Mshana 165 , Arno Mueller 85 , Francis J Ndow 166 , Mark Nicol 167 , Andrew Nunn 168 , Stephen Obaro 169 , Christina W Obiero 170 , Iruka N Okeke 171 , Uduak Okomo 172 , Tochi J Okwor 173 , Rita Oladele 174 , Sylvia Omulo 175 , Pascale Ondoa 176 , Juana Medarda Ortellado de Canese 177 , Luis Ostrosky-Zeichner 178 , Maria Clara Padoveze 179 , Madhukar Pai 180 , Benjamin Park 29 , Julian Parkhill 181 , Christopher M Parry 182 , Rosanna Peeling 61 , Luísa Maria Sobreira Vieira Peixe 183 , Olga Perovic 184 , Melinda M Pettigrew 185 , Nicola Principi 186 , Céline Pulcini 187 , Nelly Puspandari 188 , Timothy Rawson 63 , Denasha Lavanya Reddy 152 , Kessendri Reddy 152 , Paulo Redner 189 , Juan Luis Rodríguez Tudela 190 , Jesús Rodríguez-Baño 191 , Susan Rogers Van Katwyk 192 , Emmanuel Roilides 193 , Christine Rollier 194 , Leslie Rollock 195 , Jean-Baptiste Ronat 196 , Etienne Ruppe 197 , Manish Sadarangani 198 , David Salisbury 199 , Mounerou Salou 200 , Luc Hervé Samison 201 , Maurizio Sanguinetti 202 , Massimo Sartelli 203 , Natalie Schellack 204 , Jeroen Schouten 205 , Mitchell J Schwaber 206 , Jeremiah Seni 207 , Abiola Senok 208 , William M Shafer 209 , Sadia Shakoor 210 , Donald Sheppard 53 , Jong-Hee Shin 211 , Sonia Sia 212 , Dawn Sievert 29 , Ishwar Singh 213 , Rupak Singla 214 , Robert Leo Skov 215 , Olusegun O Soge 216 , Rosanne Sprute 217 , Arjun Srinivasan 218 , Subasree Srinivasan 29 , Arnfinn Sundsfjord 219 , Evelina Tacconelli 220 , Sabira Tahseen 221 , Viroj Tangcharoensathien 222 , Thomas Tängdén 223 , Karin Thursky 224 , Guy Thwaites 225 , Renata Tigulini de Souza Peral 226 , Deborah Tong 85 , Hafsah Deepa Tootla 227 , Constantinos Tsioutis 228 , Katy M Turner 229 , Paul Turner 230 , Shaheed Vally Omar 231 , Wendy Wj van de Sande 232 , Susan van den Hof 233 , Rogier van Doorn 234 , Balaji Veeraraghavan 235 , Paul Verweij 236 , Retno Wahyuningsih 237 , Hui Wang 238 , Adilia Warris 239 , Hillard Weinstock 240 , Evelyn Wesangula 241 , David Whiley 218 , Peter J White 242 , Phoebe Williams 243 , Yonghong Xiao 244 , Martin Yagui Moscoso 245 , Hsu Li Yang 246 , Sachiyo Yoshida 85 , Yunsong Yu 247 , Dorota Żabicka 248 , Matteo Zignol 85 , Igor Rudan 249
Affiliations
- 1 Antimicrobial Resistance Division, WHO, Geneva, Switzerland. Electronic address: bertagnolios@who.int.
- 2 Antimicrobial Resistance Division, WHO, Geneva, Switzerland.
- 3 Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK; Institute of Medical Microbiology, University of Münster, Münster, Germany.
- 4 Division of Paediatric Infectious Diseases, Department for Women's and Children's Health, University of Padua, Padua, Italy.
- 5 Global Tuberculosis Programme, WHO, Geneva, Switzerland.
- 6 Global HIV, Hepatitis and STI Programme, WHO, Geneva, Switzerland.
- 7 Department of Immunization, Vaccines & Biologicals, WHO, Geneva, Switzerland.
- 8 Department of Integrated Health Services, WHO, Geneva, Switzerland.
- 9 Library and Digital Information Networks, WHO, Kobe, Japan.
- 10 Public Health Department, Canton of Vaud, Lausanne, Switzerland; Infectious Diseases Service, Lausanne University Hospital, Lausanne, Switzerland.
- 11 Oxford University Clinical Research Unit Indonesia, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
- 12 University of Oxford, United Kingdom.
- 13 Institut Pasteur, Université Paris Cité, National Reference Center for Invasive Mycoses and Antifungals, Translational Mycology research group, Mycology Department, Paris, France; Laboratoire de parasitologie-mycologie, AP-HP, Hôpital Saint-Louis, Paris, France.
- 14 Instituto de Salud Carlos III, Spain.
- 15 St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia and American medical center, Addis Ababa, Ethiopia.
- 16 University of South Carolina School of Medicine; Prisma Health-Midlands, Columbia, South Carolina, United States of America.
- 17 KU Leuven, Belgium.
- 18 Ministry of Health, Oman.
- 19 Salmaniya Medical Complex, Bahrain.
- 20 Alfaisal University in Riyadh, Saudi Arabia; Previously King Faisal Specialist Hospital and Research Center in Jeddah, Saudi Arabia.
- 21 National Institute of Health, Pakistan.
- 22 Kirby Institute, UNSW Sydney, Australia.
- 23 American University of Beirut - Medical Center, Lebanon.
- 24 Ministerio de Salud, Costa Rica.
- 25 Norwegian Institute of Public Health, Norway.
- 26 UK Health Security Agency, United Kingdom.
- 27 Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Mahosot Hospital, Vientiane, Lao PDR; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
- 28 Fondation Mérieux, France.
- 29 Centers for Disease Control and Prevention, United States of America.
- 30 Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh.
- 31 Department of Genetics, University of Cambridge, Downing Place, Cambridge, United Kingdom.
- 32 Global Antibiotic R&D Partnership (GARDP).
- 33 Pathcare, South Africa.
- 34 Ramón y Cajal Institute for Health Research, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Spain.
- 35 Ministerio de Salud de la Nación, Argentina.
- 36 Barcelona Institute for Global Health (ISGlobal), Spain.
- 37 University of Genoa, Italy.
- 38 ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, India.
- 39 University of Sydney, Australia.
- 40 Dirección de Epidemiología, Ministerio de Salud Pública y Asistencia Social, Dominican Republic.
- 41 KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya; Centre for Tropical Medicine & Global Health, University of Oxford, UK.
- 42 Rajan Babu Institute for Pulmonary Medicine and Tuberculosis, India.
- 43 St George's University of London, United Kingdom; University of Basel Children's Hospital, Switzerland.
- 44 The University of Melbourne; Murdoch Children's Research Institute; Department of Gastroenterology and Clinical Nutrition, The Royal Children's Hospital.
- 45 Gulu University, Uganda.
- 46 Cleveland VA Medical Center, Case Western Reserve University, United States of America.
- 47 University of California, San Diego, School of Medicine.
- 48 Monash University, Australia.
- 49 Clínica Universitária de Pediatria, Faculdade de Medicina, Universidade de Coimbra, Portugal.
- 50 University of Cape Town, South Africa.
- 51 University College London, United Kingdom.
- 52 Victorian Infectious Diseases Unit, Royal Melbourne Hospital, Australia; Department of Infectious Diseases, University of Melbourne, Australia.
- 53 Public Health Agency of Canada, Canada.
- 54 Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.
- 55 IRCCS Istituto Giannina Gaslini, Italy.
- 56 European Medicines Agency, Netherlands.
- 57 Organisation for Economic Co-operation and Development (OECD), France.
- 58 University of Zambia, Zambia.
- 59 Johns Hopkins University School of Medicine; Johns Hopkins Center for Tuberculosis Research; Johns Hopkins Center for AIDS Research.
- 60 Doodhadhari Burfani Hospital and Research Institute, Haridwar, India.
- 61 London School of Hygiene and Tropical Medicine, United Kingdom.
- 62 Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore, India.
- 63 Imperial College London, United Kingdom.
- 64 UCSF Curry International Tuberculosis Center, United States of America.
- 65 Center for Infectious Disease Research and Policy, United States of America.
- 66 Medical Mycology Unit, Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi; National Reference Laboratory For Antimicrobial Resistance in Fungal Pathogens, Medical Mycology Unit, Department of Microbiology, Patel Chest Institute, University of Delhi, Delhi, India.
- 67 Médecins Sans Frontières, Switzerland.
- 68 Jigme Dorji Wangchuck National Referral Hospital, Bhutan.
- 69 Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
- 70 The Aurum Institute, Parktown, South Africa; Department of Medicine, Vanderbilt University, Nashville, TN, US.
- 71 San Raffaele Scientific Institute, Italy.
- 72 University of Zurich, Institute for Implementation Science in Health Care, Zurich, Switzerland.
- 73 Children's Hospital of Philadelphia /University of Pennsylvania School of Medicine, United States of America.
- 74 STI Reference Laboratory, UKHSA, London, UK.
- 75 University of Calgary and Alberta Health Services, Canada.
- 76 Servicio Antimicrobianos - INEI ANLIS Dr Carlos G. Malbrán, Argentina.
- 77 Johns Hopkins University School of Medicine, United States of America.
- 78 Institute of Infectious Diseases and Molecular Medicine, Division of Medical Microbiology, University of Cape Town.
- 79 National Jewish Center, United States of America.
- 80 MRC Unit The Gambia at the LSHTM.
- 81 University of Sheffield, United Kingdom.
- 82 University of Liverpool, United Kingdom.
- 83 Ministry of Health, Paraguay.
- 84 Clinical Center of the University Sarajevo, Bosnia and Herzegovina.
- 85 World Health Organization, Geneva, Switzerland.
- 86 Division of Infectious Disease and Tropical Medicine, German Center for Infection Research (DZIF) partner site, University Hospital Heidelberg, Germany.
- 87 University of Saskatchewan, Canada.
- 88 Stellenbosch University, South Africa.
- 89 Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
- 90 University of Parma, Italy.
- 91 Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
- 92 Universitas Diponegoro, Indonesia.
- 93 Aga Khan University, Karachi, Pakistan.
- 94 School of Medicine, University of St Andrews, St Andrews, UK and Liverpool School of Tropical Medicine, Liverpool, UK.
- 95 FIND, Switzerland.
- 96 Treatment Action Group, United States of America.
- 97 Universidade Federal de São Paulo, Brazil.
- 98 Department of Health Science, University of Florence and Infectious Disease Unit, Meyer Children's Hospital, IRCCS, Florence, Italy.
- 99 Washington University School of Medicine in St. Louis, United States of America.
- 100 Children's Hospital of Philadelphia, United States of America.
- 101 Karolinska Institute, Sweden.
- 102 National Institute for Communicable Diseases, South Africa.
- 103 Institut Pasteur de Côte d'Ivoire, Ivory Coast.
- 104 National Institute of Public Health, Bamako-Mali, Mali.
- 105 Tartu University Clinic, Estonia.
- 106 Department of General Medicine, Royal Children's Hospital, Antimicrobials Group, Murdoch Children's Research Institute, Department of Paediatrics, The University of Melbourne.
- 107 Westerdijk Fungal Biodiversity Institute (WI-KNAW), Netherlands.
- 108 University Hospital Geneva (HUG), Switzerland.
- 109 Ministry of Health, St Vincent & the Grenadines.
- 110 Helmholtz Centre for Infection Research, Switzerland.
- 111 Technical University of Denmark, Denmark.
- 112 University College London (UCL), United Kingdom.
- 113 Medical University of Graz, Austria.
- 114 University of Alabama at Birmingham, United States of America.
- 115 Supreme Council for University Hospitals, Egypt.
- 116 Central Health Laboratory, Ministry of Health and Wellness, Mauritius.
- 117 Institute of Tropical Medicine, Antwerp, Belgium.
- 118 Médecins Sans Frontières Access Campaign, Switzerland.
- 119 The Aga Khan University, Pakistan.
- 120 National Reference Center of Bacteriology - INCIENSA, Costa Rica.
- 121 University of Utah, United States of America.
- 122 Medicines, Technologies, and Pharmaceutical Services (MTaPS) Program, Management Sciences for Health, United States of America.
- 123 North DMC Medical College and Hindu Rao Hospital, India.
- 124 Director Eastern Africa, Drugs for Neglected Diseases Initiative, Nairobi, Kenya.
- 125 Oxford University Clinical Research Unit Nepal, Nepal.
- 126 Professor of Pediatrics and Medical Education, The Burnett School of Medicine at Texas Christian University, Fort Worth, TX, United States of America.
- 127 Independent Consultant, South Africa.
- 128 University Hospital Basel, Switzerland.
- 129 Health, Nutrition and Population Global Practice, World Bank Group, United States of America.
- 130 Children´s Hospital, University of Helsinki and HUS, Helsinki, Finland.
- 131 Division of Internal Medicine, Houston, TX, United States of America.
- 132 Ex-Director professor, Department of Pharmacology, V. P. Chest Institute, University of Delhi, India.
- 133 Smolensk State Medical University, Russia.
- 134 Labtests Auckland, New Zealand.
- 135 WHO Collaborating Centre for ST and AMR, NSWHP Microbiology, The Prince of Wales Hospital, NSW, Australia.
- 136 Public Health Ontario, Canada.
- 137 Hospital General Tijuana, ISESALUD de Baja California, Mexico.
- 138 University of Gothenburg, Sweden.
- 139 Institute of Hygiene and Medical Microbiology European Excellence Center of Medical Mycology (ECMM), Medical University of Innsbruck, Innsbruck, Germany.
- 140 St. George's University of London, United Kingdom; Makerere University, Kampala, Uganda.
- 141 Severance Hospital, Yonsei University Medical College, Republic of Korea.
- 142 Universidade de São Paulo, Brazil.
- 143 Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Bangkok, Thailand; Department of Tropical Hygiene, Faculty of Tropical Medicine, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
- 144 Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, Brazil.
- 145 University of Naples Federico II, Italy.
- 146 All India Institute of Medical Sciences, India.
- 147 McMaster University, Canada.
- 148 Jewish General Hospital, Montreal, Canada.
- 149 National Centre for Infectious Diseases; Tan Tock Seng Hospital; Yong Loo Lin School of Medicine; Lee Kong Chian School of Medicine, Singapore.
- 150 Asgar Ali Hospital, Dhaka; Bangladesh Lung Foundation; Formerly at Institute of Epidemiology, Disease Control and Research (IEDCR), Mahakhali, Dhaka, Bangladesh.
- 151 Universidade Católica Portuguesa, Portugal.
- 152 University of the Witwatersrand, South Africa.
- 153 University Hospital Centre Zagreb, Department of Clinical Microbiology, Infection Prevention and Control, Zagreb, Croatia.
- 154 Tan Tock Seng, Hospital and National Centre for Infectious Diseases, Singapore.
- 155 National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
- 156 WHO, Ministry of Health and Child Care, Zimbabwe.
- 157 Children's Hospital of Fudan University, National Children's Medical Center, China.
- 158 University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen-Bonn- Cologne-Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Cologne, Germany.
- 159 Governo do Estado da Paraíba, Brazil.
- 160 Ministério da Saúde, Brazil.
- 161 Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa; South African Medical Research Council Vaccine and Infectious Diseases Analytics (VIDA) Research Unit, University of the Witwatersrand, Johannesburg, South Africa.
- 162 University Hospital Bonn, Institute for Hygiene & Public Health, Germany.
- 163 National Public Health Laboratory, Tanzania.
- 164 Regional Health and Social Agency, Emilia Romagna Region, Italy.
- 165 Catholic University of Health and Allied Sciences, Tanzania.
- 166 Skin and GU Medicine Clinic, Harare, Zimbabwe.
- 167 University of Western Australia, Australia.
- 168 MRC Clinical Trials Unit at University College London, United Kingdom.
- 169 University of Nebraska Medical Center, United States of America.
- 170 Kenya Medical Research Insistute - Wellcome Trust Research Programme, Kenya.
- 171 University of Ibadan, Nigeria.
- 172 MRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Gambia.
- 173 Nigeria Centre for Disease Control and Prevention, Nigeria.
- 174 College of Medicine, University of Lagos, Nigeria.
- 175 Washington State University, United States of America.
- 176 African Society for Laboratory Medicine (ASLM), Ethiopia.
- 177 Universidad Nacional de Asunción, Paraguay.
- 178 University of Texas Health Science Center at Houston, United States of America.
- 179 School of Nursing, University of São Paulo, Brazil.
- 180 McGill University, Canada.
- 181 University of Cambridge, United Kingdom.
- 182 Liverpool School of Tropical Medicine, United Kingdom.
- 183 Faculdade de Farmácia, Universidade do Porto, Portugal.
- 184 National Institute for Communicable Diseases a division of NHLS, South Africa.
- 185 Yale School of Public Health, United States of America.
- 186 University of Milan, Italy.
- 187 Université de Lorraine et CHRU Nancy, APEMAC et Centre régional en antibiothérapie du Grand Est AntibioEst, Nancy, France.
- 188 Health Policy Agency, Ministry of Health Indonesia, Indonesia.
- 189 FIOCRUZ, Brazil.
- 190 Global Action for Fungal Infections, United Kingdom.
- 191 Unidad Clínica de Enfermedades Infecciosas y Microbiología, Instituto de Biomedicina de Sevilla (IBiS)/CSIC, Hospital Universitario Virgen Macarena; Departamento de Medicina, Universidad de Sevilla, Seville, Spain. CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.
- 192 Global Strategy Lab, Canada.
- 193 Infectious Diseases Unit, 3rd Department Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, and Hippokration General Hospital, Thessaloniki, Greece.
- 194 University of Surrey, United Kingdom.
- 195 Ministry of Health and Wellness, Barbados.
- 196 IQLS, France.
- 197 Université de Paris, France.
- 198 University of British Columbia, Canada.
- 199 Programme for Global Health, Chatham House, London, United Kingdom.
- 200 Université de Lomé, Togo.
- 201 Centre d'infectiologie Charles Mérieux, University of Antananarivo, Madagascar.
- 202 Fondazione Policlinico Universitario A. Gemelli IRCCS, Italy.
- 203 Department of Surgery, Macerata Hospital, Italy.
- 204 University of Pretoria, South Africa.
- 205 Radboud University, Netherlands.
- 206 National Center for Infection Control, Israel Ministry of Health, Israel.
- 207 Catholic University of Health and Allied Sciences (CUHAS), Mwanza, Tanzania.
- 208 College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates; School of Dentistry, Cardiff University, Cardiff, United Kingdom.
- 209 Emory University School of Medicine, United States of America.
- 210 Aga Khan University, Pakistan.
- 211 Chonnam National University Medical School, Republic of Korea.
- 212 Research Institute for Tropical Medicine, Philippines.
- 213 Antimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom; Antimicrobial Drug Discovery, Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool, United Kingdom.
- 214 National Institute of Tuberculosis and Respiratory diseases, New Delhi, India.
- 215 International Centre for Antimicrobial Resistance Solutions (ICARS).
- 216 University of Washington, Seattle, United States of America.
- 217 Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany.
- 218 University of Queensland, Australia.
- 219 UiT The Arctic University of Norway, Norway.
- 220 University of Verona, Italy.
- 221 National Tuberculosis Control Program, Pakistan.
- 222 International Health Policy Program, Ministry of Public Health, Thailand.
- 223 Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
- 224 University of Melbourne, Australia.
- 225 University of Oxford, Vietnam.
- 226 Ministry of Health, Brazil.
- 227 National Health Laboratory Services, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
- 228 European University Cyprus, Nicosia, Cyprus.
- 229 Aquarius Population Health, United Kingdom.
- 230 Cambodia-Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia; and Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.
- 231 National Institute for Communicable Diseases, a division of the National Health Laboratory Service, South Africa.
- 232 Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Netherlands.
- 233 National Institute for Public Health and the Environment, Netherlands.
- 234 Ha Noi Oxford University Clinical Research Unit, University of Oxford, United Kingdom.
- 235 Christian Medical College, India.
- 236 Radboudumc - CWZ Center of Expertise for Mycology; Center for Infectious Disease Research, Diagnostics and Laboratory Surveillance, the Netherlands.
- 237 Department of Parasitology, Universitas Indonesia, Faculty of Medicine, Jakarta, Indonesia; Department of Parasitology, Universitas Kristen Indonesia, Faculty of Medicine, Jakarta, Indonesia.
- 238 Peking University People's Hospital, Beijing, China.
- 239 MRC Centre for Medical Mycology, University of Exeter, United Kingdom.
- 240 No institutional affiliation, United States of America.
- 241 East Central and Southern Africa Health Community, Arusha, Tanzania.
- 242 Imperial College London, United Kingdom; United Kingdom Health Security Agency, United Kingdom.
- 243 University of Sydney / Sydney Children's Hospital Network, Australia.
- 244 Zhejiang University, China.
- 245 Instituto Nacional de Salud, Peru, and Universidad Nacional Mayor de San Marcos, Peru.
- 246 National University of Singapore, Singapore.
- 247 Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, China.
- 248 National Medicines Institute, Warsaw, Poland.
- 249 The University of Edinburgh, United Kingdom.
- PMID: 39146948
- PMCID: PMC11543637
- DOI: 10.1016/S2666-5247(24)00134-4
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Abstract
The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.
Copyright © 2024. Published by Elsevier Ltd.
Conflict of interest statement
Declaration of interests SBe, ZD, CMC, HHB, NG, MH-A, BA, HS, TW, BDH, and VI are WHO employees. KVW and ACa were WHO employees. KUK and SBu are WHO consultants. ACh, DD, RLH, and IDO were WHO consultants. RLH is also supported by the Wellcome Trust (106680/Z/14/Z). All authors declare no other competing interests. Declarations of competing interests of the collaborators for the WHO research agenda for AMR in human health were reviewed and are available upon request to the corresponding author.
Figures
Figure 1
Identification of the 40 research…
Figure 1
Identification of the 40 research priorities in the WHO agenda for research on…
Identification of the 40 research priorities in the WHO agenda for research on antimicrobial resistance and human health LMICs=low-income and middle-income countries.
Figure 2
Details of experts involved (A)…
Figure 2
Details of experts involved (A) Geographical distribution of experts. (B) Number of experts…
Details of experts involved (A) Geographical distribution of experts. (B) Number of experts by research discipline (data missing for 15 experts). (C) Number of experts in each antimicrobial resistance area (experts could report more than one research discipline and area of expertise).
References
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- The Lancet Antimicrobial resistance: an agenda for all. Lancet. 2024;403:2349. - PubMed
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- WHO . World Health Organization; Geneva: Jan 1, 2016. Global action plan on antimicrobial resistance.https://iris.who.int/handle/10665/253236
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- WHO . World Health Organization; Geneva: Sept 4, 2017. Prioritization of pathogens to guide discovery, research and development of new antibiotics for drug-resistant bacterial infections, including tuberculosis.https://www.who.int/publications/i/item/WHO-EMP-IAU-2017.12
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- WHO . World Health Organization; Geneva: Oct 25, 2022. WHO fungal priority pathogens list to guide research, development and public health action.https://apps.who.int/iris/handle/10665/363682
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