Connectome-based fingerprinting: reproducibility, precision, and behavioral prediction

Abstract

Functional magnetic resonance imaging-based functional connectivity enables the non-invasive mapping of individual differences in brain functional organization to individual differences in a vast array of behavioral phenotypes. This flexibility has renewed the search for neuroimaging-based biomarkers that exhibit reproducibility, prediction, and precision. Functional connectivity-based measures that share these three characteristics are key to achieving this goal. Here, we review the functional connectome fingerprinting approach and discuss its value, not only as a simple and intuitive conceptualization of the "functional connectome" that provides new insights into how the connectome is altered in association with psychiatric symptoms, but also as a straightforward and interpretable method for indexing the reproducibility of functional connectivity-based measures. We discuss how these advantages provide new avenues for strengthening reproducibility, precision, and behavioral prediction for functional connectomics and we consider new directions toward discovering better biomarkers for neuropsychiatric conditions.