Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov;50(1):328-329.
doi: 10.1038/s41386-024-01968-2.

Democratizing technologies in psychiatry: non-human primate neuroanatomy paves the way for accessible neurofeedback in the wild

Lucas R Trambaiolli  1   2 , Jamie D Feusner  3   4   5
Affiliations

Democratizing technologies in psychiatry: non-human primate neuroanatomy paves the way for accessible neurofeedback in the wild

Lucas R Trambaiolli et al. Neuropsychopharmacology. 2024 Nov.

Erratum in

No abstract available

PubMed Disclaimer

Conflict of interest statement

LRT is an Editorial Intern for Neuropsychopharmacology. JDF has nothing to disclose.

Figures

Fig. 1
Fig. 1. Pipeline for region of interest (ROI) identification and electrode placement.
Step 1: Place a non-human primate (NHP) tracer injection at the region homologous to the fMRI neurofeedback target (e.g., the amygdala). Step 2: Use the direction of fiber tracts in the NHP tracer data as a prior for estimating fiber orientation in an individual human participant’s diffusion MRI (dMRI) data to identify cortical structural targets. Step 3: Identify candidate region of interest (ROI) sublocations of voxels with functional connectivity in locations comparable to NHP anatomical connections. Step 4: Select optimal individualized ROIs by comparing the functional MRI (fMRI) functional connectivity strengths in the human brain and the input (primarily cell bodies) or output (primarily axon terminals) density strengths in the NHP tracer data, according to the dynamic model used. Examples included in this illustration are adapted from Trambaiolli et al. [5].
See this image and copyright information in PMC

References

    1. Pindi P, Houenou J, Piguet C, Favre P. Real-time fMRI neurofeedback as a new treatment for psychiatric disorders: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2022;119:110605. - DOI - PubMed
    1. Keynan JN, Cohen A, Jackont G, Green N, Goldway N, Davidov A, et al. Electrical fingerprint of the amygdala guides neurofeedback training for stress resilience. Nat Hum Behav. 2019;3:63–73. - DOI - PubMed
    1. Grisot G, Haber SN, Yendiki A. Diffusion MRI and anatomic tracing in the same brain reveal common failure modes of tractography. Neuroimage. 2021;239:118300. 10.1016/j.neuroimage.2021.118300 - DOI - PMC - PubMed
    1. Miranda-Dominguez O, Mills BD, Grayson D, Woodall A, Grant KA, Kroenke CD, et al. Bridging the gap between the human and macaque connectome: a quantitative comparison of global interspecies structure-function relationships and network topology. J Neurosci. 2014;34:5552–63. 10.1523/JNEUROSCI.4229-13.2014 - DOI - PMC - PubMed
    1. Trambaiolli L, Maffei C, Dann E, Biazoli C Jr, Bezgin G, Yendiki A, et al. Translation of monosynaptic circuits underlying amygdala fMRI neurofeedback training. Neuropsychopharmacol. 2024. 10.1038/s41386-024-01944-w - DOI - PMC - PubMed

LinkOut - more resources