Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Aug 1:15:1418897.
doi: 10.3389/fimmu.2024.1418897. eCollection 2024.

Mast cell stabilizers: from pathogenic roles to targeting therapies

Mengda Cao  1 , Yao Gao  2
Affiliations
Review

Mast cell stabilizers: from pathogenic roles to targeting therapies

Mengda Cao et al. Front Immunol. .

Abstract

Mast cells (MCs) are bone-marrow-derived haematopoietic cells that are widely distributed in human tissues. When activated, they will release tryptase, histamine and other mediators that play major roles in a diverse array of diseases/disorders, including allergies, inflammation, cardiovascular diseases, autoimmune diseases, cancers and even death. The multiple pathological effects of MCs have made their stabilizers a research hotspot for the treatment of related diseases. To date, the clinically available MC stabilizers are limited. Considering the rapidly increasing incidence rate and widespread prevalence of MC-related diseases, a comprehensive reference is needed for the clinicians or researchers to identify and choose efficacious MC stabilizers. This review analyzes the mechanism of MC activation, and summarizes the progress made so far in the development of MC stabilizers. MC stabilizers are classified by the action mechanism here, including acting on cell surface receptors, disturbing signal transduction pathways and interfering exocytosis systems. Particular emphasis is placed on the clinical applications and the future development direction of MC stabilizers.

Keywords: MC stabilizers; activation; clinical application; mechanism; targeted.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
A highly simplified mechanism for MC degranulation and the action mechanism of MC stabilizers.
Figure 2
Figure 2
The structure of some MC stabilizers.
See this image and copyright information in PMC

References

    1. Rozenberg I, Sluka SH, Rohrer L, Hofmann J, Becher B, Akhmedov A, et al. Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins. Arterioscler Thromb Vasc Biol. (2010) 30:923–30. doi: 10.1161/ATVBAHA.109.201079 - DOI - PubMed
    1. Pettipher R. The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses. Br J Pharmacol. (2008) 153 Suppl 1:S191–9. doi: 10.1038/sj.bjp.0707488 - DOI - PMC - PubMed
    1. Frangogiannis N. Transforming growth factor-beta in tissue fibrosis. J Exp Med. (2020) 217:e20190103. doi: 10.1084/jem.20190103 - DOI - PMC - PubMed
    1. Zhang E, Zhang Y, Fan Z, Cheng L, Han S, Che H. Apigenin inhibits histamine-induced cervical cancer tumor growth by regulating estrogen receptor expression. Molecules. (2020) 25:1960. doi: 10.3390/molecules25081960 - DOI - PMC - PubMed
    1. Ribatti D. Mast cells and macrophages exert beneficial and detrimental effects on tumor progression and angiogenesis. Immunol Lett. (2013) 152:83–8. doi: 10.1016/j.imlet.2013.05.003 - DOI - PubMed

LinkOut - more resources