The headache research priorities: Research goals from the American Headache Society and an international multistakeholder expert group

Todd J Schwedt¹, Amynah A Pradhan², Michael L Oshinsky³, Mitchell F Brin^{4

5}, Howard Rosen⁶, Nim Lalvani⁷, Andrew Charles⁸, Messoud Ashina⁹, Thien Phu Do⁹, Rami Burstein^{10

11}, Amy A Gelfand¹², David W Dodick^{1

13}, Patricia Pozo-Rosich¹⁴, Richard B Lipton¹⁵, Jessica Ailani¹⁶, Christina L Szperka¹⁷, Larry Charleston 4th¹⁸, Kathleen B Digre¹⁹, Andrew F Russo²⁰, Dawn C Buse^{15

21}, Scott W Powers^{22

23}, Cristina Tassorelli^{24

25}, Peter J Goadsby^{8

26}; Headache Research Priorities Working Group Members

Collaborators, Affiliations

Collaborators

Headache Research Priorities Working Group Members:
Messoud Ashina, Mitchell F Brin, Catherine D Chong, Roberto De Icco, Thien Phu Do, Debbie Hay, Nazia Karsan, Delphine Magis, Ron van Oosterhout, Shuu-Jiun Wang, Bendik Winsvold, Andrew Charles, Greg Dussor, Phil Holland, Else Tolner, Alexandra Sinclair, Kirk Johnson, William Renthal, Rami Burstein, Amy A Gelfand, Simon Akerman, K C Brennan, Meghan Buzby, Andrea Harriott, Rigmor Jensen, Arn van den Maagdenberg, Arne May, Anne MacGregor, Carrie Beth Robertson, David W Dodick, Patricia Pozo-Rosich, Sheena Aurora, Roger Cady, Hans Christoph Diener, Raquel Gil-Gouveia, Lyn Griffiths, Nim Lalvani, Christine Lay, Mi Ji Lee, Elizabeth Leroux, Marco Lisicki, Julio Pascual, Mario Peres, Jessica Ailani, Richard B Lipton, Cynthia Armand, Mark Burish, Brett Dabruzzo, Ali Ezzati, Beth Morton, Lawrence Newman, Aynur Ozge, Todd Smitherman, Amaal Starling, R J Wirth, I V Larry Charleston, Christina L Szperka, Hope O'Brien, Mario Peres, Jaime Sanders, Bert Vargas, Rebecca Erwin Wells, Kathleen B Digre, Andrew F Russo, Andy Ahn, Michael Burton, Steven Galetta, Cathey Glaser, Frederick Godley, Mary Heinricher, Andrew Hershey, Michael L Oshinsky, Ana Recober, Matthew Robbins, Gretchen Tietjen, Dawn C Buse, Scott W Powers, Joanna Kempner, Shirley Kessel, Emily Law, Jim McGinley, Mia Minen, Alexandra Ross, Elizabeth Seng, Robert Shapiro

Affiliations

¹ Mayo Clinic, Phoenix, Arizona, USA.
² Washington University School of Medicine, St. Louis, Missouri, USA.
³ National Institutes of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
⁴ AbbVie, Irvine, California, USA.
⁵ Department of Neurology, University of California Irvine, Irvine, California, USA.
⁶ American Headache Society, Mount Royal, New Jersey, USA.
⁷ American Migraine Foundation, New York, New York, USA.
⁸ University of California Los Angeles, Los Angeles, California, USA.
⁹ Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
¹⁰ Department of Anesthesia, Harvard Medical School, Boston, Massachusetts, USA.
¹¹ Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
¹² Child & Adolescent Headache Program, University of California San Francisco, San Francisco, California, USA.
¹³ Atria Academy of Science and Medicine, New York, New York, USA.
¹⁴ Hospital Universitari Vall d'Hebron, Barcelona, Spain.
¹⁵ Albert Einstein College of Medicine, Bronx, New York, USA.
¹⁶ Georgetown University Hospital, Washington, DC, USA.
¹⁷ Perelman School of Medicine at the University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
¹⁸ Michigan State University College of Human Medicine, East Lansing, Michigan, USA.
¹⁹ University of Utah, Salt Lake City, Utah, USA.
²⁰ University of Iowa, Iowa City, Iowa, USA.
²¹ Vector Psychometric Group, Chapel Hill, North Carolina, USA.
²² Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
²³ Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
²⁴ University of Pavia, Pavia, Italy.
²⁵ IRCCS Mondino Foundation, Pavia, Italy.
²⁶ NIHR King's Clinical Research Facility, King's College London, London, UK.

PMID: 39149968
DOI: 10.1111/head.14797

The headache research priorities: Research goals from the American Headache Society and an international multistakeholder expert group

Todd J Schwedt et al. Headache. 2024 Sep.

. 2024 Sep;64(8):912-930.

doi: 10.1111/head.14797. Epub 2024 Aug 16.

Authors

Collaborators

Headache Research Priorities Working Group Members:
Messoud Ashina, Mitchell F Brin, Catherine D Chong, Roberto De Icco, Thien Phu Do, Debbie Hay, Nazia Karsan, Delphine Magis, Ron van Oosterhout, Shuu-Jiun Wang, Bendik Winsvold, Andrew Charles, Greg Dussor, Phil Holland, Else Tolner, Alexandra Sinclair, Kirk Johnson, William Renthal, Rami Burstein, Amy A Gelfand, Simon Akerman, K C Brennan, Meghan Buzby, Andrea Harriott, Rigmor Jensen, Arn van den Maagdenberg, Arne May, Anne MacGregor, Carrie Beth Robertson, David W Dodick, Patricia Pozo-Rosich, Sheena Aurora, Roger Cady, Hans Christoph Diener, Raquel Gil-Gouveia, Lyn Griffiths, Nim Lalvani, Christine Lay, Mi Ji Lee, Elizabeth Leroux, Marco Lisicki, Julio Pascual, Mario Peres, Jessica Ailani, Richard B Lipton, Cynthia Armand, Mark Burish, Brett Dabruzzo, Ali Ezzati, Beth Morton, Lawrence Newman, Aynur Ozge, Todd Smitherman, Amaal Starling, R J Wirth, I V Larry Charleston, Christina L Szperka, Hope O'Brien, Mario Peres, Jaime Sanders, Bert Vargas, Rebecca Erwin Wells, Kathleen B Digre, Andrew F Russo, Andy Ahn, Michael Burton, Steven Galetta, Cathey Glaser, Frederick Godley, Mary Heinricher, Andrew Hershey, Michael L Oshinsky, Ana Recober, Matthew Robbins, Gretchen Tietjen, Dawn C Buse, Scott W Powers, Joanna Kempner, Shirley Kessel, Emily Law, Jim McGinley, Mia Minen, Alexandra Ross, Elizabeth Seng, Robert Shapiro

Affiliations

¹ Mayo Clinic, Phoenix, Arizona, USA.
² Washington University School of Medicine, St. Louis, Missouri, USA.
³ National Institutes of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
⁴ AbbVie, Irvine, California, USA.
⁵ Department of Neurology, University of California Irvine, Irvine, California, USA.
⁶ American Headache Society, Mount Royal, New Jersey, USA.
⁷ American Migraine Foundation, New York, New York, USA.
⁸ University of California Los Angeles, Los Angeles, California, USA.
⁹ Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
¹⁰ Department of Anesthesia, Harvard Medical School, Boston, Massachusetts, USA.
¹¹ Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
¹² Child & Adolescent Headache Program, University of California San Francisco, San Francisco, California, USA.
¹³ Atria Academy of Science and Medicine, New York, New York, USA.
¹⁴ Hospital Universitari Vall d'Hebron, Barcelona, Spain.
¹⁵ Albert Einstein College of Medicine, Bronx, New York, USA.
¹⁶ Georgetown University Hospital, Washington, DC, USA.
¹⁷ Perelman School of Medicine at the University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
¹⁸ Michigan State University College of Human Medicine, East Lansing, Michigan, USA.
¹⁹ University of Utah, Salt Lake City, Utah, USA.
²⁰ University of Iowa, Iowa City, Iowa, USA.
²¹ Vector Psychometric Group, Chapel Hill, North Carolina, USA.
²² Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
²³ Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
²⁴ University of Pavia, Pavia, Italy.
²⁵ IRCCS Mondino Foundation, Pavia, Italy.
²⁶ NIHR King's Clinical Research Facility, King's College London, London, UK.

PMID: 39149968
DOI: 10.1111/head.14797

Abstract

Objective: To identify and disseminate research priorities for the headache field that should be areas of research focus during the next 10 years.

Background: Establishing research priorities helps focus and synergize the work of headache investigators, allowing them to reach the most important research goals more efficiently and completely.

Methods: The Headache Research Priorities organizing and executive committees and working group chairs led a multistakeholder and international group of experts to develop headache research priorities. The research priorities were developed and reviewed by clinicians, scientists, people with headache, representatives from headache organizations, health-care industry representatives, and the public. Priorities were revised and finalized after receiving feedback from members of the research priorities working groups and after a public comment period.

Results: Twenty-five research priorities across eight categories were identified: human models, animal models, pathophysiology, diagnosis and management, treatment, inequities and disparities, research workforce development, and quality of life. The priorities address research models and methods, development and optimization of outcome measures and endpoints, pain and non-pain symptoms of primary and secondary headaches, investigations into mechanisms underlying headache attacks and chronification of headache disorders, treatment optimization, research workforce recruitment, development, expansion, and support, and inequities and disparities in the headache field. The priorities are focused enough that they help to guide headache research and broad enough that they are widely applicable to multiple headache types and various research methods.

Conclusions: These research priorities serve as guidance for headache investigators when planning their research studies and as benchmarks by which the headache field can measure its progress over time. These priorities will need updating as research goals are met and new priorities arise.

Keywords: diagnosis; disparities; migraine; pathophysiology; quality of life; treatment.

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References

REFERENCES

1. Ashina M. Migraine. N Engl J Med. 2020;383:1866‐1876.
1. Ashina M, Terwindt GM, Al‐Karagholi MA, et al. Migraine: disease characterisation, biomarkers, and precision medicine. Lancet. 2021;397:1496‐1504.
1. Alpuente A, Gallardo VJ, Asskour L, Caronna E, Torres‐Ferrus M, Pozo‐Rosich P. Salivary CGRP and erenumab treatment response: towards precision medicine in migraine. Ann Neurol. 2022;92:846‐859.
1. Ashina M, Hansen JM, á Dunga BO, Olesen J. Human models of migraine—short‐term pain for long‐term gain. Nat Rev Neurol. 2017;13:713‐724.
1. Bergerot A, Holland PR, Akerman S, et al. Animal models of migraine: looking at the component parts of a complex disorder. Eur J Neurosci. 2006;24:1517‐1534.

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The headache research priorities: Research goals from the American Headache Society and an international multistakeholder expert group

Collaborators

Affiliations

The headache research priorities: Research goals from the American Headache Society and an international multistakeholder expert group

Authors

Collaborators

Affiliations

Abstract

References

REFERENCES

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous