Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct 7;221(10):e20240002.
doi: 10.1084/jem.20240002. Epub 2024 Aug 16.

A path forward for Staphylococcus aureus vaccine development

Stephanie A Fritz  1 , Juliane Bubeck Wardenburg  1
Affiliations

A path forward for Staphylococcus aureus vaccine development

Stephanie A Fritz et al. J Exp Med. .

Abstract

The pursuit of a vaccine to quell Staphylococcus aureus disease has been unfruitful. In this Viewpoint, we explore the biological linkage between microbial niche acquisition and host immunity as a basis to guide future vaccine efforts.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Conceptual framework for use of an immunoscore to inform S. aureus vaccine development. Humans exhibit heterogeneity of the host immune response to S. aureus. Positioning the field to develop and implement a functional assessment of the protective immune response (displayed as quantifiable traits A–E) will enable risk stratification of the population that has been exposed to S. aureus. The application of this PISA can be utilized to guide targeted vaccine-based interventions. Illustration created with https://BioRender.com.
See this image and copyright information in PMC

References

    1. GBD 2019 Antimicrobial Resistance Collaborators . 2022. Lancet. 10.1016/S0140-6736(22)02185-7 - DOI
    1. Bruni, D., et al. . 2020. Nat. Rev. Cancer. 10.1038/s41568-020-0285-7 - DOI - PubMed
    1. Caldera, J.R., et al. . 2024. Cell Rep. Med. 10.1016/j.xcrm.2023.101360 - DOI
    1. Creech, C.B. 2022. Cell Host Microbe. 10.1016/j.chom.2022.07.005 - DOI - PubMed
    1. Graham, D.B., and Xavier R.J.. 2023. Trends Immunol. 10.1016/j.it.2023.05.002 - DOI

MeSH terms

Substances