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Multicenter Study
. 2024 Dec:275:114241.
doi: 10.1016/j.jpeds.2024.114241. Epub 2024 Aug 14.

Parental Report of Indoor Air Pollution Is Associated with Respiratory Morbidities in Bronchopulmonary Dysplasia

Jessica L Rice  1 , Joseph M Collaco  2 , Michael C Tracy  3 , Catherine A Sheils  4 , Lawrence M Rhein  5 , Antonia P Popova  6 , Paul E Moore  7 , Audrey N Miller  8 , Winston M Manimtim  9 , Khanh Lai  10 , Jacob A Kaslow  7 , Lystra P Hayden  4 , Julie L Fierro  1 , Manvi Bansal  11 , Eric D Austin  7 , Brianna Aoyama  12 , Stamatia Alexiou  1 , Gangaram Akangire  9 , Amit Agarwal  13 , Natalie Villafranco  14 , Roopa Siddaiah  15 , Joanne M Lagatta  16 , Mehtap Haktanir Abul  17 , A Ioana Cristea  18 , Christopher D Baker  19 , Steven H Abman  19 , Sharon A McGrath-Morrow  1
Affiliations
Multicenter Study

Parental Report of Indoor Air Pollution Is Associated with Respiratory Morbidities in Bronchopulmonary Dysplasia

Jessica L Rice et al. J Pediatr. 2024 Dec.

Abstract

Objective: To determine the association between indoor air pollution and respiratory morbidities in children with bronchopulmonary dysplasia (BPD) recruited from the multicenter BPD Collaborative.

Study design: A cross-sectional study was performed among participants <3 years old in the BPD Collaborative Outpatient Registry. Indoor air pollution was defined as any reported exposure to tobacco or marijuana smoke, electronic cigarette emissions, gas stoves, and/or wood stoves. Clinical data included acute care use and chronic respiratory symptoms in the past 4 weeks.

Results: A total of 1011 participants born at a mean gestational age of 26.4 ± 2.2 weeks were included. Most (66.6%) had severe BPD. More than 40% of participants were exposed to ≥1 source of indoor air pollution. The odds of reporting an emergency department visit (OR, 1.7; 95% CI, 1.18-2.45), antibiotic use (OR, 1.9; 95% CI, 1.12-3.21), or a systemic steroid course (OR, 2.18; 95% CI, 1.24-3.84) were significantly higher in participants reporting exposure to secondhand smoke (SHS) compared with those without SHS exposure. Participants reporting exposure to air pollution (not including SHS) also had a significantly greater odds (OR, 1.48; 95% CI, 1.08-2.03) of antibiotic use as well. Indoor air pollution exposure (including SHS) was not associated with chronic respiratory symptoms or rescue medication use.

Conclusions: Exposure to indoor air pollution, especially SHS, was associated with acute respiratory morbidities, including emergency department visits, antibiotics for respiratory illnesses, and systemic steroid use.

Keywords: Fine particulate matter; PM(2.5); gas stoves; secondhand smoke.

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Conflict of interest statement

Declaration of Competing Interest Supported by the NIH (JLR: K23ES029985). All authors disclose that they have no financial interests in the subject of this manuscript.

References

    1. EPA. US. Integraged Science Assessment (ISA) for Particulate Matter (final report, Dec 2009). Washington, DC: U.S. Environmental Protection Agency; 2009.
    1. Jedrychowski W, Bendkowska I, Flak E, et al. Estimated risk for altered fetal growth resulting from exposure to fine particles during pregnancy: an epidemiologic prospective cohort study in Poland. Environmental health perspectives 2004;112:1398–402. - PMC - PubMed
    1. Woodruff TJ, Parker JD, Schoendorf KC. Fine particulate matter (PM2.5) air pollution and selected causes of postneonatal infant mortality in California. Environmental health perspectives 2006;114:786–90. - PMC - PubMed
    1. Hunt A, Crawford JA, Rosenbaum PF, Abraham JL. Levels of household particulate matter and environmental tobacco smoke exposure in the first year of life for a cohort at risk for asthma in urban Syracuse, NY. Environment international 2011;37:1196–205. - PubMed
    1. Gehring U, Wijga AH, Hoek G, et al. Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study. The Lancet Respiratory medicine 2015;3:933–42. - PubMed

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