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. 2024 Aug 16;14(1):19018.
doi: 10.1038/s41598-024-70097-z.

Relative value of novel systemic immune-inflammatory indices and classical hematological parameters in predicting depression, suicide attempts and treatment response

Putrada Ninla-Aesong  1   2 , Pongtorn Kietdumrongwong  3 , Sudan Prasad Neupane  4 , Pavarud Puangsri  5 , Haruthai Jongkrijak #  6 , Potiga Chotipong #  7 , Pakin Kaewpijit #  8
Affiliations

Relative value of novel systemic immune-inflammatory indices and classical hematological parameters in predicting depression, suicide attempts and treatment response

Putrada Ninla-Aesong et al. Sci Rep. .

Abstract

This study compared the power of the novel inflammatory markers systemic immune inflammation index (SII) and the system inflammation response index (SIRI) versus the classical hematological indices neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and platelet counts in distinguishing between major depressive disorder (MDD) with and without suicide attempts and distinguishing the non-response to selective serotonin reuptake inhibitor (SSRI) treatment. A total of 139 young adult MDD patients and 54 healthy controls (HC) were included. We found that, in comparison to HC, baseline NLR, PLR, SII, and SIRI were significantly higher in MDD patients, but only NLR and SII had area under the ROC curve (AUC) values greater than 0.7. MDD patients with suicide attempts (SA) showed significantly higher baseline MLR and SIRI, and a tendency to increase NLR compared to those without SA. In terms of AUC, sensitivity, and specificity, NLR was better than MLR, SIRI, SII, and PLR in distinguishing SA. Non-responders to SSRI treatment showed a significant increase in baseline platelet count and PLR compared to responders with an AUC greater than 0.7. These findings highlight the potential benefit of combining novel and classical hematological indices in predicting depression, suicide attempts and treatment response.

Keywords: Depression outcomes; Neutrophil-to-lymphocyte ratio (NLR); Platelet count; Platelet-to-lymphocyte ratio (PLR); Systemic immune-inflammation index (SII); Systemic inflammation response index (SIRI).

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Conflict of interest statement

PK and PK are employed by the Bangkok Dusit Medical Services PLC, Thailand. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The receiver operating characteristic (ROC) curve of baseline inflammatory markers for the prediction of MDD. NLR neutrophil-to-lymphocyte ratio, MLR monocyte-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, SII systemic immune-inflammatory index, SIRI systemic inflammation response index.
Figure 2
Figure 2
The receiver operating characteristic (ROC) curve of baseline inflammatory markers for the prediction of suicide attempts in patients with MDD. NLR neutrophil-to-lymphocyte ratio, MLR monocyte-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, SII systemic immune-inflammatory index, SIRI systemic inflammation response index.
Figure 3
Figure 3
The receiver operating characteristic (ROC) curve of baseline platelet count and inflammatory markers for the prediction of having no response to SSRI treatment in patients with MDD. NLR neutrophil-to-lymphocyte ratio, MLR monocyte-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, SII systemic immune-inflammatory index, SIRI systemic inflammation response index.
See this image and copyright information in PMC

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