Distributed circuits regulating defensive state transitions: freezing, flight and fight

Chandrashekhar D Borkar^{1

2}, Jonathan P Fadok^{3

4}

Affiliations

¹ Department of Psychology, Tulane University, New Orleans, LA, 70118, USA.
² Tulane Brain Institute, Tulane University, New Orleans, LA, 70118, USA.
³ Department of Psychology, Tulane University, New Orleans, LA, 70118, USA. jfadok@tulane.edu.
⁴ Tulane Brain Institute, Tulane University, New Orleans, LA, 70118, USA. jfadok@tulane.edu.

Chandrashekhar D Borkar et al. Neuropsychopharmacology. 2024 Nov.

. 2024 Nov;50(1):320-321.

doi: 10.1038/s41386-024-01965-5.

Chandrashekhar D Borkar^{1

2}, Jonathan P Fadok^{3

4}

¹ Department of Psychology, Tulane University, New Orleans, LA, 70118, USA.
² Tulane Brain Institute, Tulane University, New Orleans, LA, 70118, USA.
³ Department of Psychology, Tulane University, New Orleans, LA, 70118, USA. jfadok@tulane.edu.
⁴ Tulane Brain Institute, Tulane University, New Orleans, LA, 70118, USA. jfadok@tulane.edu.

Erratum in

Correction: Neuropsychopharmacology Volume 50 Issue 1.
[No authors listed] [No authors listed] Neuropsychopharmacology. 2025 May;50(6):1019-1020. doi: 10.1038/s41386-025-02087-2. Neuropsychopharmacology. 2025. PMID: 40108440 Free PMC article. No abstract available.

No abstract available

The authors declare no competing interests.

1. Fadok JP, Krabbe S, Markovic M, Courtin J, Xu C, Massi L, et al. A competitive inhibitory circuit for selection of active and passive fear responses. Nature. 2017;542:96–9. - PubMed
1. Massi L, Hagihara KM, Courtin J, Hinz J, Müller C, Fustiñana MS, et al. Disynaptic specificity of serial information flow for conditioned fear. Sci Adv 2023;9:1–9. - PMC - PubMed
1. Borkar CD, Stelly CE, Fu X, Dorofeikova M, Le QE, Vutukuri R, et al. Top-down control of flight by a non-canonical cortico-amygdala pathway. Nature. 2024;625:743–9. - PMC - PubMed
1. Nordman J, Ma X, Li Z. Traumatic stress induces prolonged aggression increase through synaptic potentiation in the medial amygdala circuits. eNeuro. 2020;7:1–14. - PMC - PubMed
1. Falkner AL, Wei D, Song A, Watsek LW, Chen I, Chen P, et al. Hierarchical representations of aggression in a hypothalamic-midbrain circuit. Neuron. 2020;106:637–648.e6. - PMC - PubMed