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Comparative Study
. 2025 Apr 1;64(4):1760-1769.
doi: 10.1093/rheumatology/keae450.

Multimodal imaging of structural damage and inflammation in psoriatic arthritis: a comparison of DMARD-naive and DMARD-failure patients

Nağme Ö Renkli  1 , Nienke J Kleinrensink  1   2 , Julia Spierings  1 , Simon Mastbergen  1 , Harald E Vonkeman  3   4 , Shasti C Mooij  3 , Lydia G Schipper  5 , Amin Herman  6 , Iris Ten Katen  2 , Frank J Nap  2 , Marjolein E Hol  2 , Pim A de Jong  2 , Mylène P Jansen  1 , Wouter Foppen  2 ; TOFA-PREDICT Author Group
Collaborators, Affiliations
Comparative Study

Multimodal imaging of structural damage and inflammation in psoriatic arthritis: a comparison of DMARD-naive and DMARD-failure patients

Nağme Ö Renkli et al. Rheumatology (Oxford). .

Abstract

Objectives: To compare inflammatory and structural differences in active PsA between DMARD-naive and DMARD-failure patients using diverse imaging approaches for future analyses. Additionally, to explore the influence of patient characteristics (clinical and demographic variables) on imaging findings.

Methods: Of the 80 patients included from the first cohort of the ongoing multicentre TOFA-PREDICT trial, 40 were DMARD-naive and 40 were DMARD-failure (csDMARD failure; one prior bDMARD excluding etanercept was allowed), all meeting classification criteria for PsA with a minimum disease duration of eight weeks. Baseline conventional radiographs of hands and feet, MRIs of both ankles, and whole-body [18F]-fluorodeoxyglucose PET/CT (18F-FDG PET/CT) were evaluated for inflammatory and structural imaging parameters, including Sharp-van der Heijde (SHS), Heel Enthesitis Magnetic Resonance Imaging Scoring System (HEMRIS) and Deauville synovitis scoring. Differences between groups and the influence of patient characteristics were examined with multiple linear regression.

Results: At baseline, patient characteristics were similar between groups. Imaging parameters showed limited inflammation and structural damage. Inflammatory imaging parameters were not significantly different (P > 0.200). Among structural parameters, only HEMRIS Achilles tendon structural damage was significantly different (P = 0.024, R2 = 0.071) and SHS Joint Space Narrowing was not statistically significant (P = 0.050, R2 = 0.048) with higher values for both in DMARD failures. After correction of patient characteristics, these differences in imaging disappeared (both P > 0.600).

Conclusion: At baseline, PsA patient groups were comparable concerning structural and inflammatory imaging parameters, especially after correcting for patient characteristics. Thus, DMARD-naive and DMARD-failure patient groups may be combined in future PsA progression and treatment decision studies.

Trial registration: www.clinicaltrialsregister.eu. EudraCT: 2017-003900-28.

Keywords: HEMRIS; MRI; PET/CT; PsA; conventional radiographs; imaging; psoriatic arthritis.

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Figures

Figure 1.
Figure 1.
Illustration of between-group differences for inflammatory imaging parameters. Each circle represents an individual, and the line represents the median value of the group
Figure 2.
Figure 2.
Illustration of between-group differences for structural imaging parameters. Each circle represents an individual, and the line represents the median value of the group. HEMRIS structure Achilles tendon (P = 0.024) was statistically significant whereas SHS JSN (P = 0.050) was not significant
See this image and copyright information in PMC

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