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Case Reports
. 2024 Oct;15(28):1975-1988.
doi: 10.1111/1759-7714.15420. Epub 2024 Aug 18.

Bronchiolar adenoma/ciliated muconodular papillary tumor complicated by lymphoid interstitial pneumonia in a patient with Sjögren's disease: A case report and systematic review

Pinar Çağan  1 , Ali Kimiaei  1 , Seyedehtina Safaei  1 , Houssam Eddine Youcefi  1 , Alara Abu Saadeh  1 , Feride Yaman  2 , Özlem Yapıcıer  3 , Cemal Asim Kutlu  1
Affiliations
Case Reports

Bronchiolar adenoma/ciliated muconodular papillary tumor complicated by lymphoid interstitial pneumonia in a patient with Sjögren's disease: A case report and systematic review

Pinar Çağan et al. Thorac Cancer. 2024 Oct.

Abstract

Bronchiolar adenoma (BA)/ciliated muconodular papillary tumor (CMPT) is a rare pulmonary neoplasm, with less than 150 cases documented in the literature. We report a unique case of BA/CMPT complicated by lymphoid interstitial pneumonia (LIP) in a 55-year-old male with Sjögren's disease. This is the first documented instance of such a comorbidity. Through a systematic review of PubMed, we also summarize the demographic, clinical, radiological, histopathological, and treatment characteristics of CMPT.

Keywords: CMPT; Sjögren's disease; ciliated muconodular papillary tumor; lung tumor; lymphoid interstitial pneumonia.

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Conflict of interest statement

The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

FIGURE 1
FIGURE 1
PRISMA diagram illustrating the flow of study selection in the systematic review.
FIGURE 2
FIGURE 2
Computed tomography scans showing widespread ground‐glass opacities, septal thickening, fibro atelectatic changes and traction bronchiectasis.
FIGURE 3
FIGURE 3
X20, hematoxylin and eosin, nodules (arrows) located in the subpleural region.
FIGURE 4
FIGURE 4
X100, hematoxylin and eosin, adenoid and papillary structures with mucin pools.
FIGURE 5
FIGURE 5
X200, Goblet cell (black arrow), scattered immunopositivity for TTF1 (green arrow).
FIGURE 6
FIGURE 6
X100, CK7, diffuse positivity.
FIGURE 7
FIGURE 7
X200, basal cells showing positivity for p63.
FIGURE 8
FIGURE 8
X400, carcinoembryonic antigen (CEA), luminal immunopositivity.
See this image and copyright information in PMC

References

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