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. 2025 Feb;80(2):584-587.
doi: 10.1111/all.16284. Epub 2024 Aug 19.

Higher levels of basal serum tryptase are associated with sensitization, FeNO, allergic morbidity, and lower control of allergic asthma in teenagers from the PARIS birth cohort

Yannick Chantran  1   2   3 , Simone Choi  1   3 , Céline Roda  1 , Pascale Nicaise-Roland  4 , Luc de Chaisemartin  4 , Sylvie Chollet-Martin  4 , Michel Arock  2   5 , Fanny Rancière  1 , Isabelle Momas  1
Affiliations

Higher levels of basal serum tryptase are associated with sensitization, FeNO, allergic morbidity, and lower control of allergic asthma in teenagers from the PARIS birth cohort

Yannick Chantran et al. Allergy. 2025 Feb.
No abstract available

Keywords: Tryptase; allergy; asthma; biomarker; birth cohort; drug reactions; eczema/dermatitis; hypersensitivity; mast cells; sensitization; teenagers.

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Conflict of interest statement

Y. Chantran serves in scientific advisory board for ThermoFisher Scientific, received honoraria from ThermoFisher Scientific, and research grants from Blueprint Medicines and ThermoFisher Scientific. M. Arock receives research grant from Blueprint Medicines, and serves on advisory boeard and receives honoraria from AB Science, Blueprint Medicines, Novartis and ThermoFisher Scientific. The rest of the authors declare that they have no relevant conflict of interest.

Figures

FIGURE 1
FIGURE 1
Adjusted odds ratios of allergy‐related outcomes according to bST levels: Multivariable logistic regression models in teenagers from the PARIS birth cohort. Adjusted odds ratios are depicted in red when their 95% confidence interval does not include 1. All models were adjusted for: Age, sex, weight, number of children in the household, history of active tabagism, high socio‐economic status, presence of furry pets at home, signs of house dampness (from 0 to 5). Levels of FeNO were also adjusted for current corticosteroid intake, active smoking or secondhand smoking the day of measurement, physical activity or coffee or tea consumption <2 h before measurement, blood eosinophils, any sensitization to inhaled or food allergens. Clinical manifestations models were also adjusted for parental history of allergy, sampling during spring or summer. All VIFs were <1.58. Considered sensitizations were to any inhaled allergen for asthma and rhinitis, and to any inhaled or food allergens for dermatitis. AOR, adjusted odds ratio; bST, basal serum tryptase; FeNO, exhaled fraction of nitric oxide; ppb, part per billion; VIF, Variance Inflation Factor.
FIGURE 2
FIGURE 2
Asthma control scores and bST levels in asthmatic teenagers of the PARIS cohort. Grey: Overall asthmatic participants. Purple: Asthmatic participants displayed positive skin prick test and/or specific IgE to tested inhaled allergens. Orange: Asthmatic participants displayed negative skin prick test and specific IgE to tested inhaled allergens. P‐value for trend is from Jonckheere‐Terpstra test. *p <.05; **p <.01.
See this image and copyright information in PMC

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