Rhinovirus Pneumonia, Rhabdomyolysis-Induced Acute Kidney Injury, and Post-Viral Forme Fruste Lupus

Abstract

Viral interstitial pneumonia is rarely associated with rhabdomyolysis-induced acute kidney injury (AKI) and evolving systemic lupus erythematosus (SLE) with no lupus flare. Here, we report an adult male with human rhinovirus-associated viral pneumonia and rhabdomyolysis-related AKI requiring dialysis. He was detected to be anti-nuclear, anti-Smith, and anti-U1 ribonucleoprotein antibodies positive. His kidney biopsy revealed normal glomeruli, with immunofluorescence showing a full-house pattern. Renal function and lung function gradually improved to normal without any immunosuppressants.

Keywords: Acute kidney injury; Rhabdomyolysis; Rhinovirus; Systemic lupus erythematosus.

Figure 1:

(a) NCCT chest lung window (axial section): multifocal areas of ground glass opacities with few areas of consolidation, consistent with acute interstitial pneumonia. (b) Renal biopsy (H and E, 400×). Normal glomerulus with tubules showing acute tubular necrosis. The interstitium is edematous with few inflammatory cells. H and E = hematoxylin and eosin, NCCT = noncontrast computerized tomography.