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. 2024 Dec;29(12):1058-1066.
doi: 10.1111/resp.14817. Epub 2024 Aug 19.

Ventilation heterogeneity is increased in adults exposed to coal mine fire-related PM2.5

Thomas McCrabb  1   2 , Brigitte Borg  1   2 , Caroline X Gao  1   3 , Catherine Smith  1   3 , Claire F O'Sullivan  1   2 , David Brown  1 , Jillian Ikin  1 , Annie Makar  2 , Tyler Lane  1 , Michael J Abramson  1 , Bruce R Thompson  4
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Free article

Ventilation heterogeneity is increased in adults exposed to coal mine fire-related PM2.5

Thomas McCrabb et al. Respirology. 2024 Dec.
Free article

Abstract

Background and objectives: The Hazelwood Health Study was set up to study long-term health effects of a mine fire that blanketed residents of the Latrobe Valley with smoke for 45 days in 2014. The Respiratory Stream specifically assessed the impact of fine particulate matter <2.5 μm diameter (PM2.5) exposure from mine fire smoke on lung health. The multiple breath nitrogen washout (MBW) test assesses ventilation heterogeneity, which may detect sub-clinical airways dysfunction not identified using standard tests such as spirometry. This analysis assessed the association of PM2.5 exposure with measures of ventilation heterogeneity.

Methods: Exposed (Morwell) and unexposed (Sale) participants were recruited 3.5-4 years after the fire from those who had participated in an Adult Survey. MBW was performed to measure lung clearance index (LCI), functional residual capacity (FRC), acinar (Sacin) and conductive (Scond) ventilation heterogeneity. PM2.5 exposure was estimated with emission and chemical transport models. Multivariable linear regression models were fitted controlling for confounders.

Results: We recruited 519 participants. MBW tests were conducted on 504 participants with 479 acceptable test results (40% male; 313 exposed, 166 unexposed). Exposure to mine fire-related PM2.5 was associated with increasing Scond (β = 1.57/kL, 95%CI: 0.20-2.95, p = 0.025), which was comparable to the estimated effect on Scond of 4.7 years of aging. No other MBW outcomes were statistically different.

Conclusion: Increasing exposure to PM2.5 was associated with increased ventilation heterogeneity in the conductive region of the lungs 4 years after the event.

Keywords: PM2.5; air pollution; coal mine fire; lung; multiple breath nitrogen washout; ventilation heterogeneity.

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References

REFERENCES

    1. Reisen F, Fisher G, Torre P, Marshall A, Cope M, Emmerson K, et al. Analysis of air quality during the Hazelwood mine fire. In: Environment protection authority. Carlton, VIC; 2016.
    1. Taylor S, Borg B, Gao C, Brown D, Hoy R, Makar A, et al. The impact of the Hazelwood coal mine fire smoke exposure on asthma. J Asthma. 2022;59:213–222.
    1. Prasad S, Gao CX, Borg B, Broder J, Brown D, Ikin JF, et al. Chronic obstructive pulmonary disease in adults exposed to fine particles from a coal mine fire. Ann Am Thorac Soc. 2022;19:186–195.
    1. Holt NR, Gao CX, Borg BM, Brown D, Broder JC, Ikin J, et al. Long‐term impact of coal mine fire smoke on lung mechanics in exposed adults. Respirology. 2021;26:861–868.
    1. Li R, Zhou R, Zhang J. Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases (review). Oncol Lett. 2018;15:7506–7514.

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