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Randomized Controlled Trial
. 2024 Aug 19;19(8):e0308800.
doi: 10.1371/journal.pone.0308800. eCollection 2024.

Early Occupational Therapy Intervention post-stroke (EOTIPS): A randomized controlled trial

Patricia García-Pérez  1   2   3   4 , María Carmen Rodríguez-Martínez  3   5 , Alejandro Gallardo-Tur  6 , Encarnación Blanco-Reina  4   5   7 , Carlos de la Cruz-Cosme  5   6   8 , José Pablo Lara  1   4   5
Affiliations
Randomized Controlled Trial

Early Occupational Therapy Intervention post-stroke (EOTIPS): A randomized controlled trial

Patricia García-Pérez et al. PLoS One. .

Abstract

Background: Occupational therapy (OT) is an effective evidence-based intervention that positively influences stroke patients'independence recovery, leading to new opportunities for better quality of life outcomes.

Objectives: To explore the effectiveness of an early OT intervention program (EOTIPS) in the process of hospital to home discharge after stroke in Spain.

Material and methods: We conducted a prospective, randomized controlled clinical trial that included 60 adults who suffered a stroke and were discharged home. Participants assigned to the experimental group (n = 30) were included in EOTIPS and compared with a control group (n = 30). Evaluations assessed quality of life (Stroke and Aphasia Quality of Life Scale [SAQOL-39]), functional independence (Modified Rankin Scale [mRS], Barthel Index [BI] and Stroke Impact Scale-16 [SIS-16]), perceptual-cognitive skills (Montreal Cognitive Assessment [MoCA]), upper limb function (Fugl Meyer Assessment [FMA]), mobility (Berg Balance Scale [BBS] and Timed Up & Go [TUG]), communication skills (Communicative Activity Log [CAL]) and mood disorders (Beck Depression Inventory-II [BDI-II] and Hamilton Anxiety Scale [HAM-A]); they were completed within two weeks post-stroke and after three months follow-up. Statistical analysis included intent-to-treat analysis, considering all participants (dropouts as failures), and efficacy analysis, considering only end-of-treatment participants.

Results: Participants in the intervention group showed a significant better evolution in the main outcome measure of quality of life (SAQOL-39 p = .029), as well as for independence (mRSp = .004), perceptual-cognitive skills (MoCA p = .012)and symptoms of depression (BDI-II p = .011) compared to the control group.

Conclusions: EOTIPS was effective in improving quality of life, as well as enhancing perceptual-cognitive skills, independence and reducing levels of depression for patients who suffered a stroke in a Spanish cohort and could be considered as an applicable non-pharmacologic therapeutic tool that can lead to patients' positive outcomes after stroke. This study was registered on ClinicalTrials.gov with the identifier NCT04835363.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Rehabilitation pathway.
Fig 2
Fig 2. Trial profile.
Fig 3
Fig 3. Significant outcome measures.
Fig 4
Fig 4. mRS graphic comparing pre-post score results.
See this image and copyright information in PMC

References

    1. Díaz-Guzmán J, Egido JA, Gabriel-Sánchez R, Barberá-Comes G, Fuentes-Gimeno B, Fernández-Pérez C, et al.. Stroke and transient ischemic attack incidence rate in Spain: the IBERICTUS study. Cerebrovasc Dis. 2012:34(4):272–81. doi: 10.1159/000342652 - DOI - PubMed
    1. Ezekiel L, Collett J, Mayo NE, Pang L, Field L, Dawes H. Factors Associated With Participation in Life Situations for Adults With Stroke: A Systematic Review. Arch Phys Med Rehabil. 2019. May;100(5):945–55. doi: 10.1016/j.apmr.2018.06.017 - DOI - PubMed
    1. Rafsten L, Danielsson A, Nordin A, Björkdahl A, Lundgren-Nilsson A, Larsson MEH, et al.. Gothenburg Very Early Supported Discharge study (GOTVED): a randomised controlled trial investigating anxiety and overall disability in the first year after stroke. BMC Neurol. 2019;19(1):277. doi: 10.1186/s12883-019-1503-3 - DOI - PMC - PubMed
    1. Rasmussen RS, Østergaard A, Kjær P, Skerris A, Skou C, Christoffersen J, et al.. Stroke rehabilitation at home before and after discharge reduced disability and improved quality of life: a randomised controlled trial. Clin Rehabil. 2016;30(3):225–36. doi: 10.1177/0269215515575165 - DOI - PubMed
    1. Feng W, Yu H, Wang J, Xia J. Applicationeffectofthe hospital-community integrated service model in home rehabilitation of stroke in disabled elderly: a randomised trial. Ann Palliat Med. 2021;10(4):4670–7. doi: 10.21037/apm-21-602 - DOI - PubMed

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