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Comment
. 2024 Aug 27;121(35):e2414324121.
doi: 10.1073/pnas.2414324121. Epub 2024 Aug 19.

Pipe dream: Remyelination therapy for multiple sclerosis

Benjamin Deneen  1   2   3
Affiliations
Comment

Pipe dream: Remyelination therapy for multiple sclerosis

Benjamin Deneen. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Competing interests statement:The author declares no competing interest.

Figures

Fig. 1.
Fig. 1.
Loss of myelin on neuronal axons is a hallmark feature of MS. The PIPE-307 compound functions as an antagonist of M1R receptors, which are expressed on oligodendrocyte precursors (OLPs). This antagonism of M1R on OLPs stimulates their differentiation into myelinating OLs. PIPE-307-mediated generation of myelinating OLs stimulates the remyelination of axons and the restoration of neuronal function. Figure was generated using biorender.com.
See this image and copyright information in PMC

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References

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