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. 2024 Aug 19;14(1):19151.
doi: 10.1038/s41598-024-69819-0.

Association between systemic immune-inflammation index and cardiovascular-kidney-metabolic syndrome

Chenxuan Gao #  1 , Shizhen Gao #  1 , Renpei Zhao #  1 , Peimin Shen #  1 , Xiaorui Zhu  1 , Yane Yang  1 , Conghao Duan  1 , Yansi Wang  1 , Huan Ni  1 , Lanping Zhou  1 , Yunfang Xiang  1 , MeiJu Li  1 , Zhao Xu  1 , Yibing Wang  1 , Haijie Yang  2 , Chuanwei Zhao  3
Affiliations

Association between systemic immune-inflammation index and cardiovascular-kidney-metabolic syndrome

Chenxuan Gao et al. Sci Rep. .

Abstract

This study aims to explore the relationship between the Systemic Immune-Inflammation Index (SII) and Cardiovascular-Kidney-Metabolic (CKM) Syndrome and its components. Data from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2018 were analyzed. CKM Syndrome is defined as the coexistence of Cardiometabolic Syndrome (CMS) and Chronic Kidney Disease (CKD). The SII is calculated using the formula: SII = (Platelet count × Neutrophil count)/Lymphocyte count. Weighted logistic regression models were used to examine the associations between SII and CKM, as well as its specific components. Restricted cubic splines explored non-linear relationships, and piecewise linear regression models assessed threshold effects. A consistent positive correlation was observed between elevated SII levels and the likelihood of CKM and its related diseases. In the fully adjusted Model 3, an increase of 1000 units in SII was associated with a 1.48-fold increase in the odds of CKM (95% CI 1.20-1.81, p < 0.001). Quartile analysis revealed a dose-response relationship, with the highest quartile of SII (Q4) showing the strongest association with CKM and its components. Nonlinear analyses revealed inflection points for waist circumference, triglycerides, low HDL-C, and cardiometabolic syndrome at specific SII levels, indicating a change in the direction or strength of associations beyond these points. Conversely, a linear relationship was observed between SII and chronic kidney disease. The SII is positively correlated with the risk of CKM Syndrome and its individual components, with evidence of non-linear relationships and threshold effects for some components.

Keywords: Cardiometabolic syndrome; Cardiovascular-kidney-metabolic syndrome; Chronic kidney disease; National health and nutrition examination survey; Systemic immune-inflammation index.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Screening flow of respondents.
Figure 2
Figure 2
Nonlinear relationship between SII and Cardiovascular-Kidney-Metabolic Syndrome (A). Nonlinear relationship between SII and elevated Waist Circumference (B). Nonlinear relationship between SII and Elevated Triglycerides (C). Nonlinear relationship between SII and Low HDL-C (D). Nonlinear relationship between SII and Elevated Fasting Plasma Glucose (E). Nonlinear relationship between SII and Elevated Blood Pressure (F). Nonlinear relationship between SII and Cardiometabolic Syndrome (G). Nonlinear relationship between SII and Chronic Kidney Disease (H).
Figure 2
Figure 2
Nonlinear relationship between SII and Cardiovascular-Kidney-Metabolic Syndrome (A). Nonlinear relationship between SII and elevated Waist Circumference (B). Nonlinear relationship between SII and Elevated Triglycerides (C). Nonlinear relationship between SII and Low HDL-C (D). Nonlinear relationship between SII and Elevated Fasting Plasma Glucose (E). Nonlinear relationship between SII and Elevated Blood Pressure (F). Nonlinear relationship between SII and Cardiometabolic Syndrome (G). Nonlinear relationship between SII and Chronic Kidney Disease (H).
See this image and copyright information in PMC

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