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Case Reports
. 2024 Aug 19;166(1):340.
doi: 10.1007/s00701-024-06230-8.

Multinodular and vacuolating neuronal tumor in the thalamus: case report and systematic review of literature

Thomas J On  1 , Oscar Alcantar-Garibay  1 , Yuan Xu  1 , Irakliy Abramov  1 , Jennifer M Eschbacher  2 , Nishant Tiwari  2 , Kris A Smith  3 , Mark C Preul  4
Affiliations
Case Reports

Multinodular and vacuolating neuronal tumor in the thalamus: case report and systematic review of literature

Thomas J On et al. Acta Neurochir (Wien). .

Abstract

The authors present the first reported case of MVNT in the thalamus in a 60-year-old man with a 20-year history of epilepsy and recent progressive neurological decline presented for neurosurgical evaluation for a non-enhancing mass predominantly in the right thalamus presumed to be a low-grade glioma. The tumor was subtotally resected using a left contralateral interhemispheric transcallosal approach. Histological and molecular assessment revealed an MVNT with MAPK pathway-activating mutation. The authors also conducted a systematic review of pathology-proven cases of MVNT to provide an up-to-date overview of the literature on the localization, presenting symptoms, and recurrence of this tumor.

Keywords: Glioneuronal and neuronal tumor; MAPK pathway-altered brain tumor; Neuro-oncology; Non-enhancing tumor.

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References

    1. Abramov I, Park MT, Belykh E et al (2023) Intraoperative confocal laser endomicroscopy: prospective in vivo feasibility study of a clinical-grade system for brain tumors. J Neurosurg 138(3):587–597 - DOI - PubMed
    1. Alizada O, Ayman T, Akgun MY et al (2020) Multinodular and vacuolating neuronal tumor of the cerebrum: Two cases and review of the literature. Clin Neurol Neurosurg 197:106149 - DOI - PubMed
    1. Bagatto D, Ius T, Pegolo E et al (2021) A multinodular and vacuolating neuronal tumor of the cerebrum (MVNT) with glioma-like appearance. Acta Neurol Belg 121(6):1851–1854 - DOI - PubMed
    1. Bianconi A, Bonada M, Zeppa P, et al (2023) How Reliable Is Fluorescence-Guided Surgery in Low-Grade Gliomas? A Systematic Review Concerning Different Fluorophores. Cancers (Basel).;15(16). https://doi.org/10.3390/cancers15164130
    1. Biyikli E, Kursun M, Altuntas D et al (2023) Radiological and clinical features of multinodular and vacuolating neuronal tumor (MVNT). Egypt J Neurosurg 38(1):1 - DOI

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