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Multicenter Study
. 2025 Feb;18(1):40-47.
doi: 10.1007/s12265-024-10552-4. Epub 2024 Aug 19.

H-FABP as a Biomarker in Transient Ischemic Attack

Daisy Guamán-Pilco  1 , Elvira Chocano  1 , Elena Palà  1 , Marcel Lamana-Vallverdú  1 , Anna Penalba  1 , Paula García-Rodríguez  1 , Marta Rubiera  2 , Alejandro Bustamante  3 , Àlex Rovira  4 , Soledad Pérez-Sánchez  5   6 , Leire Azurmendi  7 , Sandrine Reymond  7 , Jean-Charles Sánchez  7 , Joan Montaner  8   9   10   11
Affiliations
Multicenter Study

H-FABP as a Biomarker in Transient Ischemic Attack

Daisy Guamán-Pilco et al. J Cardiovasc Transl Res. 2025 Feb.

Abstract

The study investigates the utility of heart fatty-acid binding protein (H-FABP) in distinguishing TIA from mimics. Data from 175 patients from the StrokeChip multicenter study was retrospectively analyzed. H-FABP level was measured using a rapid point-of-care test. Findings revealed that H-FABP levels were higher in individuals with TIA compared to mimics [3.10 ng/mL (IQR 2.13-4.78) vs. 1.70 ng/mL (IQR 1.23-2.38)] (p < 0.001). The diagnostic performance of H-FABP, assessed using the area under the curve operating characteristic curve (AUC) was 0. 83 (95% CI = 0.76-0.90) for the final model, indicating good discriminative ability. The PanelomiX determined that a combined cutoff of > 1.85 ng/ml for H-FABP, age > 42.5 years, and baseline NIHSS > 3.5 had a 100% of sensitivity and 23.30% of specificity. The study suggests that H-FABP has potential as a TIA diagnostic biomarker. The rapid application of POCT's for H-FABP measurement supports its potential use in emergency departments and primary care settings.

Keywords: Biomarker; Diagnostic; H-FABP; Ischemia; MIMIC; POCT; TIA.

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Conflict of interest statement

Declarations. Ethical Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study protocol was approved by the Hospital Vall d’Hebrón Ethics Committee. Informed Consent: All patients or their relatives signed informed consent. Conflicting Interests: The authors declare that there are no conflicts of interest.

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