Comment on

• Localization of the TIG3 transglutaminase interaction domain and demonstration that the amino-terminal region is required for TIG3 function as a keratinocyte differentiation regulator.

  Jans R, Sturniolo MT, Eckert RL. Jans R, et al. J Invest Dermatol. 2008 Mar;128(3):517-29. doi: 10.1038/sj.jid.5701035. Epub 2007 Aug 30. J Invest Dermatol. 2008. Retraction in: J Invest Dermatol. 2025 Jun;145(6):1541. doi: 10.1016/j.jid.2025.03.008. PMID: 17762858 Retracted.
• The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival.

  Balasubramanian S, Adhikary G, Eckert RL. Balasubramanian S, et al. Carcinogenesis. 2010 Mar;31(3):496-503. doi: 10.1093/carcin/bgp314. Epub 2009 Dec 16. Carcinogenesis. 2010. PMID: 20015867 Free PMC article.
• PKC-delta and -eta, MEKK-1, MEK-6, MEK-3, and p38-delta are essential mediators of the response of normal human epidermal keratinocytes to differentiating agents.

  Adhikary G, Chew YC, Reece EA, Eckert RL. Adhikary G, et al. J Invest Dermatol. 2010 Aug;130(8):2017-30. doi: 10.1038/jid.2010.108. Epub 2010 May 6. J Invest Dermatol. 2010. PMID: 20445555 Free PMC article.
• Protein kinase C (PKC) delta suppresses keratinocyte proliferation by increasing p21(Cip1) level by a KLF4 transcription factor-dependent mechanism.

  Chew YC, Adhikary G, Wilson GM, Reece EA, Eckert RL. Chew YC, et al. J Biol Chem. 2011 Aug 19;286(33):28772-28782. doi: 10.1074/jbc.M110.205245. Epub 2011 Jun 7. J Biol Chem. 2011. Retraction in: J Biol Chem. 2025 Sep 13;301(10):110620. doi: 10.1016/j.jbc.2025.110620. PMID: 21652709 Free PMC article. Retracted.
• Suppression of AP1 transcription factor function in keratinocyte suppresses differentiation.

  Han B, Rorke EA, Adhikary G, Chew YC, Xu W, Eckert RL. Han B, et al. PLoS One. 2012;7(5):e36941. doi: 10.1371/journal.pone.0036941. Epub 2012 May 23. PLoS One. 2012. Retraction in: PLoS One. 2021 Feb 11;16(2):e0247222. doi: 10.1371/journal.pone.0247222. PMID: 22649503 Free PMC article. Retracted.
• p38δ regulates p53 to control p21Cip1 expression in human epidermal keratinocytes.

  Saha K, Adhikary G, Kanade SR, Rorke EA, Eckert RL. Saha K, et al. J Biol Chem. 2014 Apr 18;289(16):11443-11453. doi: 10.1074/jbc.M113.543165. Epub 2014 Mar 5. J Biol Chem. 2014. Retraction in: J Biol Chem. 2025 Sep 13;301(10):110621. doi: 10.1016/j.jbc.2025.110621. PMID: 24599959 Free PMC article. Retracted.
• Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype.

  Rorke EA, Adhikary G, Young CA, Roop DR, Eckert RL. Rorke EA, et al. J Invest Dermatol. 2015 Jan;135(1):170-180. doi: 10.1038/jid.2014.310. Epub 2014 Aug 22. J Invest Dermatol. 2015. PMID: 25050598 Free PMC article.
• The Bmi-1 helix-turn and ring finger domains are required for Bmi-1 antagonism of (-) epigallocatechin-3-gallate suppression of skin cancer cell survival.

  Balasubramanian S, Scharadin TM, Han B, Xu W, Eckert RL. Balasubramanian S, et al. Cell Signal. 2015 Jul;27(7):1336-44. doi: 10.1016/j.cellsig.2015.03.021. Epub 2015 Apr 2. Cell Signal. 2015. PMID: 25843776 Free PMC article.
• Methylosome Protein 50 and PKCδ/p38δ Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene Expression.

  Saha K, Eckert RL. Saha K, et al. J Biol Chem. 2015 May 22;290(21):13521-30. doi: 10.1074/jbc.M115.642868. Epub 2015 Apr 7. J Biol Chem. 2015. Retraction in: J Biol Chem. 2025 Sep 13;301(10):110622. doi: 10.1016/j.jbc.2025.110622. PMID: 25851901 Free PMC article. Retracted.
• Transglutaminase Interaction with α6/β4-Integrin Stimulates YAP1-Dependent ΔNp63α Stabilization and Leads to Enhanced Cancer Stem Cell Survival and Tumor Formation.

  Fisher ML, Kerr C, Adhikary G, Grun D, Xu W, Keillor JW, Eckert RL. Fisher ML, et al. Cancer Res. 2016 Dec 15;76(24):7265-7276. doi: 10.1158/0008-5472.CAN-16-2032. Epub 2016 Oct 25. Cancer Res. 2016. PMID: 27780825 Free PMC article.
• Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival.

  Kerr C, Szmacinski H, Fisher ML, Nance B, Lakowicz JR, Akbar A, Keillor JW, Lok Wong T, Godoy-Ruiz R, Toth EA, Weber DJ, Eckert RL. Kerr C, et al. Oncogene. 2017 May 25;36(21):2981-2990. doi: 10.1038/onc.2016.452. Epub 2016 Dec 12. Oncogene. 2017. PMID: 27941875 Free PMC article.
• Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation.

  Saha K, Fisher ML, Adhikary G, Grun D, Eckert RL. Saha K, et al. Carcinogenesis. 2017 Aug 1;38(8):827-836. doi: 10.1093/carcin/bgx044. Carcinogenesis. 2017. PMID: 28854561 Free PMC article.
• Inhibition of YAP function overcomes BRAF inhibitor resistance in melanoma cancer stem cells.

  Fisher ML, Grun D, Adhikary G, Xu W, Eckert RL. Fisher ML, et al. Oncotarget. 2017 Nov 22;8(66):110257-110272. doi: 10.18632/oncotarget.22628. eCollection 2017 Dec 15. Oncotarget. 2017. PMID: 29299145 Free PMC article.