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Case Reports
. 2024 Jul 23:45:100664.
doi: 10.1016/j.mmcr.2024.100664. eCollection 2024 Sep.

Cutaneous Purpureocillium lilacinum and Fusarium coinfection in a heart transplant recipient

Leonard Farrugia  1 , Veronica Baston  2 , Laura Burfield  3 , Lucy Melly  4 , Andrew M Borman  5   6 , Abhijit M Bal  1
Affiliations
Case Reports

Cutaneous Purpureocillium lilacinum and Fusarium coinfection in a heart transplant recipient

Leonard Farrugia et al. Med Mycol Case Rep. .

Abstract

Purpureocillium lilacinum and Fusarium species are increasingly recognized as significant opportunistic fungal pathogens. We report a rare case of co-infection in a 63-year old heart transplant recipient presenting with nodular skin lesions, treated successfully with voriconazole. We highlight the importance of being vigilant about co-infection with moulds as it impacts on the selection of appropriate antifungal agents. 2012 Elsevier Ltd. All rights reserved.

Keywords: Fusarium; Mycosis; Purpureocillium; Transplant; Voriconazole.

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Figures

Fig. 1
Fig. 1
Nodular skin lesions over right hand (A) & left hip (B&C).
Fig. 2
Fig. 2
Floccose,lilac-brown colonies of P.lilacinum on sabouraud's Dextrose agar. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 3
Fig. 3
Necrotising granulomas within the subcutis. (Hematoxylin & eosin stain,x40).
Fig. 4
Fig. 4
Fungal spores within the granulomatous inflammation. (Periodic acid-Schiff,x40).
See this image and copyright information in PMC

References

    1. Pappas P.G., Alexander B.D., Andes D.R., et al. Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET) Clin. Infect. Dis. 2010;50(8):1101–1111. - PubMed
    1. Shoham S., Marr K.A. Invasive fungal infections in solid organ transplant recipients. Future Microbiol. 2012 May;7(5):639–655. - PMC - PubMed
    1. Rabin A.S., Givertz M.M., Couper G.S., Shea M.M., Peixoto D., Yokoe D.S., et al. Risk factors for invasive fungal disease in heart transplant recipients. J. Heart Lung Transplant. 2015 Feb;34(2):227–232. - PMC - PubMed
    1. Hoenigl M., Salmanton-García J., Walsh T.J., Nucci M., Neoh C.F., Jenks J.D., et al. Global guideline for the diagnosis and management of rare mould infections: an initiative of the European confederation of medical Mycology in cooperation with the international society for human and animal Mycology and the American society for microbiology. Lancet Infect. Dis. 2021 doi: 10.1016/S1473-3099(20)30784-2. - DOI - PubMed
    1. Sprute R., Salmanton-García J., Sal E., Malaj X., Ráčil Z., Ruiz de Alegría Puig C., et al. Invasive infections with Purpureocillium lilacinum: clinical characteristics and outcome of 101 cases from FungiScope® and the literature. J. Antimicrob. Chemother. 2021 May 12;76(6):1593–1603. - PMC - PubMed

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