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. 2024 Aug 12:2024:9964992.
doi: 10.1155/2024/9964992. eCollection 2024.

Predictive Value of Red Cell Distribution Width-to-Platelet Ratio Combined with Procalcitonin in 28-day Mortality for Patients with Sepsis

Ying Si  1 , Bo Sun  2 , Yongmao Huang  1 , Ke Xiao  1
Affiliations

Predictive Value of Red Cell Distribution Width-to-Platelet Ratio Combined with Procalcitonin in 28-day Mortality for Patients with Sepsis

Ying Si et al. Crit Care Res Pract. .

Abstract

Objectives: The objective of this study was to investigate the predictive value of erythrocyte distribution width-to-platelet ratio (RPR) combined with procalcitonin (PCT) on 28-day mortality in patients with sepsis.

Methods: A total of 193 patients with sepsis admitted to the Affiliated Hospital of Southwest Medical University from January 2013 to January 2018 were selected as the study objects. Univariate and multivariate analyses were used to understand the indicators related to the 28-day prognosis of patients, and the ROC curve was further drawn. The Kaplan-Meier curve was used to evaluate the prognosis of patients.

Results: A total of 193 patients were enrolled and divided into the survivor group (=156) and nonsurvivor group (=37) according to the prognosis within 28 days. The median age was 62.5 years, and 64.7% were males. Multivariate analysis showed that PCT and RPR were independent risk factors for 28-day prognosis in sepsis patients. The area under the ROC curve of PCT and RPR were 0.894 and 0.861, respectively, and the cutoff values were 27.04 and 0.12, respectively. Survival curve analysis showed that PCT and RPR were associated with the 28-day prognosis of patients, and the combination of PCT and RPR had a better predictive effect.

Conclusions: PCT and RPR are independent predictors of sepsis prognosis. The combined application of PCT and RPR (PCT-RPR) can further improve the predictive performance and provide a reference for the clinical diagnosis, treatment, and prognosis evaluation of sepsis patients.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
Flowchart for patient enrollment and study design.
Figure 2
Figure 2
ROC curve analysis of PCT, RPR, and PCT-RPR for 28-day mortality of patients with sepsis.
Figure 3
Figure 3
Kaplan–Meier survival curve of 28-day mortality according to the optimal cutoff of PCT = 27.04 and RPR = 0.12.
Figure 4
Figure 4
The combination of PCT and RPR was found to enhance prognostic accuracy for patients with sepsis.
See this image and copyright information in PMC

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