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. 2024 Aug 5:15:1420402.
doi: 10.3389/fneur.2024.1420402. eCollection 2024.

Mesenchymal stem cells for peripheral nerve injury and regeneration: a bibliometric and visualization study

Aikebaierjiang Aisaiti #  1 , Shalayiding Aierxiding #  1 , Kutiluke Shoukeer #  1 , Aikeremujiang Muheremu  1   2
Affiliations

Mesenchymal stem cells for peripheral nerve injury and regeneration: a bibliometric and visualization study

Aikebaierjiang Aisaiti et al. Front Neurol. .

Abstract

Objective: To use bibliometric methods to analyze the research hotspots and future development trends regarding the application of mesenchymal stem cells in peripheral nerve injury and regeneration.

Methods: Articles published from January 1, 2013, to December 31, 2023, were meticulously screened using the MeSH terms: TS = ("Mesenchymal stem cells" AND "Peripheral nerve injury") OR TS = ("Mesenchymal stem cells" AND "Peripheral nerve regeneration") within the Web of Science database. The compiled data was then subjected to in-depth analysis with the aid of VOSviewer and Cite Space software, which facilitated the identification of the most productive countries, organizations, authors, and the predominant keywords prevalent within this research domain.

Results: An extensive search of the Web of Science database yielded 350 relevant publications. These scholarly works were authored by 2,049 collaborative researchers representing 41 countries and affiliated with 585 diverse academic and research institutions. The findings from this research were disseminated across 167 various journals, and the publications collectively cited 21,064 references from 3,339 distinct journals.

Conclusion: Over the past decade, there has been a consistent upward trajectory in the number of publications and citations pertaining to the use of mesenchymal stem cells in the realm of peripheral nerve injury and regeneration. The domain of stem cell therapy for nerve injury has emerged as a prime focus of research, with mesenchymal stem cell therapy taking center stage due to its considerable promise in the treatment of nerve injuries. This therapeutic approach holds the potential to significantly enhance treatment options and rehabilitation prospects for patients suffering from such injuries.

Keywords: Schwann cells; bibliometrics; mesenchymal stem cells; neural regeneration; peripheral nerve injury.

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Conflict of interest statement

AM was employed by Beijing Darwin Cell Biotechnology Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of literature search and screening process.
Figure 2
Figure 2
The annual distribution of publications in the Web of Science database.
Figure 3
Figure 3
Proportion of the top 10 countries in the field of academic literature publications.
Figure 4
Figure 4
National collaborative analysis of studies related to using mesenchymal stem cells for the treatment of peripheral nerve injury and regeneration.
Figure 5
Figure 5
Chart of cooperative relations among various countries.
Figure 6
Figure 6
Global distribution of the top 10 countries in terms of published literature.
Figure 7
Figure 7
Top 10 institutions and regions ranked by the number of publications in the field.
Figure 8
Figure 8
Co-authorship analysis of literature institutions.
Figure 9
Figure 9
An analysis of publication time in the journal.
Figure 10
Figure 10
Analysis of cited reference.
Figure 11
Figure 11
Distribution analysis of literature citations.
Figure 12
Figure 12
(A) Distribution analysis of keywords. (B) Time distribution analysis chart of keywords in the field. (C) Distribution of keywords in the field of mesenchymal stem cells for peripheral nerve injury and regeneration.
Figure 13
Figure 13
Distribution chart of the temporal analysis of keywords in this field.
Figure 14
Figure 14
Journal outbreak analysis of the main publications in this field.
See this image and copyright information in PMC

References

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