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Comparative Study
. 2024 Dec;28(6):2683-2691.
doi: 10.1007/s11325-024-03148-4. Epub 2024 Aug 20.

Comparison of physical activity and quality of life between obese individuals with obstructive sleep apnea syndrome and individuals with obesity hypoventilation syndrome

Aliki Karkala  1 , Antonios Baxevanidis  2 , Anastasia Chasiotou  3 , Dimitra Siopi  3 , Dimitra Mameletzi  4 , Evangelia Kouidi  4 , Diamantis Chloros  3 , Georgia Pitsiou  5 , Afroditi K Boutou  6
Affiliations
Comparative Study

Comparison of physical activity and quality of life between obese individuals with obstructive sleep apnea syndrome and individuals with obesity hypoventilation syndrome

Aliki Karkala et al. Sleep Breath. 2024 Dec.

Abstract

Purpose: Obstructive Sleep Apnea Syndrome (OSAS) and Obesity Hypoventilation Syndrome (OHS) share common causal factors and comorbidities but may have a variable effect on physical activity and associated quality of life, due to differences in pathophysiology. The aim of this study was to compare the levels of physical activity, mental health and quality of life between matched obese patients with either OSAS or OHS, aiming to identify which of the two syndromes may impose the most severe impact on these variables, for the first time in literature.

Methods: A total of 76 obese patients (OSAS: Ν1 = 48, OHS: N2 = 26) of similar age (58.2 ± 12.2 vs. 63.6 ± 9.8; p > 0.05), BMI (37.2 ± 6.2 vs. 40.3 ± 7.3; p > 0.05), and Apnea-Hypopnea Index (AHI) under non-invasive ventilation, completed International Physical Activity Questionnaire (IPAQ), Short-Form Health Questionnaire (SF-36), Personal Well-Being (PWB) Scale and Hospital Anxiety and Depression Scale (HADS-A and HADS-D), in this cross-sectional study.

Results: Both groups had similar scores in SF-36, HADS-A and HADS-D, while prevalence of clinical cases of anxiety (HADS-A > 8) and depression (HADS-D > 8) were also similar. OSAS patients scored significantly higher in physical activity [absolute IPAQ values 1100.75(7753.5) for OSAS vs. 518(3806) for OHS; p = 0.029]. Group comparisons yielded significant differences in physical functioning (p < 0.05) and general health perceptions (p < 0.05), in favor of the OSAS group.

Conclusion: Both syndromes significantly affect patients' quality of life and physical activity, with the burden being heavier for OHS patients. Daily physical activity seems to be more impaired among obese OHS patients perhaps due to daytime hypercapnia.

Keywords: 36-Item short form health survey; Obesity hypoventilation syndrome; Obstructive sleep apnea syndrome; Physical activity; Quality of life.

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Conflict of interest statement

Declarations Ethical standards This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Scientific Committee of “G. Papanikolaou” General Hospital, Thessaloniki, Greece. All participants gave their informed consent prior to their inclusion in the study. Consent for publication: not applicable. Conflict of interest The authors declare that they have no conflict of interest.

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