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. 2024 Aug 20;316(8):542.
doi: 10.1007/s00403-024-03296-3.

Distinct adaptive immune receptor feature of adipose-derived mesenchymal stem cells (AD-MSCs) treatment of psoriasis

Lipeng Tang #  1   2   3 , Danni Yao #  4 , Ziyang He  4 , Shuyan Ye  4 , Xinsheng Chen  4 , Yu Huang  5 , Qin Han  6   7 , Xiang Zeng  5 , Xirun Zheng  8 , Taohua Liu  8 , Zhe Wang  9 , Robert Chunhua Zhao  10   11 , Guangjuan Zheng  12   13   14   15 , Chuanjian Lu  16   17   18
Affiliations

Distinct adaptive immune receptor feature of adipose-derived mesenchymal stem cells (AD-MSCs) treatment of psoriasis

Lipeng Tang et al. Arch Dermatol Res. .

Abstract

Psoriasis (Ps) is one of the most common chronic inflammatory skin disorders with its pathogenesis correlated with dysregulated innate and adaptive system. Even though biological agents have advanced the treatment of psoriasis, however, there are huge limitations, like high adverse reactions and relapse rate. Therefore, it is of great interest in searching clinical resolutions with better safety and efficacy. In the current study, we utilized the adipose-derived mesenchymal stem cell (AD-MSCs) to treat moderate/severe cases of psoriasis in a single-arm clinical study. This AD-MSC treatment has proven to be clinically safe and effective. Interestingly, a trend of adaptome improvement, including increased diversity, elevated uCDR3s and decreased large clone after AD-MSC treatment in a short (2 weeks) and long (12 weeks) terms. In conclusion, allogenic AD-MSC treatment has shown a good safety and efficacy in treating Ps and can effectively improve the compromised adaptive immune system of Ps patients.

Keywords: Adaptive immune system; Adipose-derived mesenchymal stem cells; Immune repertoire; Psoriasis.

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