Meta-Analysis

. 2024 Aug 20;36(1):171.

doi: 10.1007/s40520-024-02823-6.

Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies

Justyna Godos^{1

2}, Agnieszka Micek³, Walter Currenti¹, Carlotta Franchi^{4

5}, Andrea Poli⁶, Maurizio Battino^{7

8

9}, Alberto Dolci¹⁰, Cristian Ricci¹¹, Zoltan Ungvari^{12

13

14

15

16}, Giuseppe Grosso^{17

18}

Affiliations

¹ Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
² Center for Human Nutrition and Mediterranean Foods (NUTREA), University of Catania, Catania, Italy.
³ Statistical Laboratory, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, 31-501, Poland.
⁴ Laboratory of Pharmacoepidemiology and Human Nutrition, Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, 20156, Italy.
⁵ Italian Institute for Planetary Health (IIPH), Milan, 20124, Italy.
⁶ Nutrition Foundation of Italy (NFI), Milan, 20124, Italy.
⁷ Department of Clinical Sciences, Università Politecnica Delle Marche, Ancona, Italy.
⁸ Research Group on Food, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres 21, Santander, 39011, Spain.
⁹ International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu University, Zhenjiang, Jiangsu, China.
¹⁰ Sustainable Development Department, Bolton Food SpA, Milan, 20124, Italy.
¹¹ Africa Unit for Transdisciplinary Health Research (AUTHeR), North-West University, Potchefstroom, 2531, South Africa.
¹² Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
¹³ Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
¹⁴ International Training Program in Geroscience, Department of Public Health, Doctoral College, Semmelweis University, Budapest, Hungary.
¹⁵ Stephenson Cancer Center, University of Oklahoma, Oklahoma City, OK, USA.
¹⁶ Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
¹⁷ Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy. giuseppe.grosso@unict.it.
¹⁸ Center for Human Nutrition and Mediterranean Foods (NUTREA), University of Catania, Catania, Italy. giuseppe.grosso@unict.it.

PMID: 39162889
PMCID: PMC11335789
DOI: 10.1007/s40520-024-02823-6

Meta-Analysis

Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies

Justyna Godos et al. Aging Clin Exp Res. 2024.

. 2024 Aug 20;36(1):171.

doi: 10.1007/s40520-024-02823-6.

Authors

Affiliations

¹ Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
² Center for Human Nutrition and Mediterranean Foods (NUTREA), University of Catania, Catania, Italy.
³ Statistical Laboratory, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, 31-501, Poland.
⁴ Laboratory of Pharmacoepidemiology and Human Nutrition, Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, 20156, Italy.
⁵ Italian Institute for Planetary Health (IIPH), Milan, 20124, Italy.
⁶ Nutrition Foundation of Italy (NFI), Milan, 20124, Italy.
⁷ Department of Clinical Sciences, Università Politecnica Delle Marche, Ancona, Italy.
⁸ Research Group on Food, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, Isabel Torres 21, Santander, 39011, Spain.
⁹ International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu University, Zhenjiang, Jiangsu, China.
¹⁰ Sustainable Development Department, Bolton Food SpA, Milan, 20124, Italy.
¹¹ Africa Unit for Transdisciplinary Health Research (AUTHeR), North-West University, Potchefstroom, 2531, South Africa.
¹² Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
¹³ Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
¹⁴ International Training Program in Geroscience, Department of Public Health, Doctoral College, Semmelweis University, Budapest, Hungary.
¹⁵ Stephenson Cancer Center, University of Oklahoma, Oklahoma City, OK, USA.
¹⁶ Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
¹⁷ Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy. giuseppe.grosso@unict.it.
¹⁸ Center for Human Nutrition and Mediterranean Foods (NUTREA), University of Catania, Catania, Italy. giuseppe.grosso@unict.it.

PMID: 39162889
PMCID: PMC11335789
DOI: 10.1007/s40520-024-02823-6

Abstract

Background: Cognitive impairment is projected to affect a preponderant proportion of the aging population. Lifelong dietary habits have been hypothesized to play a role in preventing cognitive decline. Among the most studied dietary components, fish consumptionhas been extensively studied for its potential effects on the human brain.

Aims: To perform a meta-analysis of observational studies exploring the association between fish intake and cognitive impairment/decline and all types of dementia.

Methods: A systematic search of electronic databases was performed to identify observational studies providing quantitative data on fish consumption and outcomes of interest. Random effects models for meta-analyses using only extreme exposure categories, subgroup analyses, and dose-response analyses were performed to estimate cumulative risk ratios (RRs) and 95% confidence intervals (CIs).

Results: The meta-analysis comprised 35 studies. Individuals reporting the highest vs. the lowest fish consumption were associated with a lower likelihood of cognitive impairment/decline (RR = 0.82, 95% CI: 0.75, 0.90, I² = 61.1%), dementia (RR = 0.82, 95% CI: 0.73, 0.93, I² = 38.7%), and Alzheimer's disease (RR = 0.80, 95% CI: 0.67, 0.96, I² = 20.3%). The dose-response relation revealed a significantly decreased risk of cognitive impairment/decline and all cognitive outcomes across higher levels of fish intake up to 30% for 150 g/d (RR = 0.70, 95% CI: 0.52, 0.95). The results of this relation based on APOE ε4 allele status was mixed based on the outcome investigated.

Conclusions: Current findings suggest fish consumption is associated with a lower risk of cognitive impairment/decline in a dose-response manner, while for dementia and Alzheimer's disease there is a need for further studies to improve the strength of evidence.

Keywords: Alzheimer’s disease; Cognitive status; Dementia; Fish; Meta-analysis.

PubMed Disclaimer

Conflict of interest statement

A.D. is an employee of Bolton Food S.P.A. The other authors have no competing interests to disclose.

Figures

**Fig. 1**
Meta-analysis of the risk of cognitive outcomes for the highest vs. the lowest fish consumption

**Fig. 2**
Graphical representation of dose-response meta-analysis of the risk of cognitive outcomes for various servings of fish intake

See this image and copyright information in PMC

References

1. GBD 2019 Diseases and Injuries Collaborators (2020) Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the global burden of Disease Study 2019. Lancet 396:1204–1222. 10.1016/S0140-6736(20)30925-9 10.1016/S0140-6736(20)30925-9 - DOI - PMC - PubMed
1. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators (2018) Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the global burden of Disease Study 2017. Lancet 392:1789–1858. 10.1016/S0140-6736(18)32279-7 10.1016/S0140-6736(18)32279-7 - DOI - PMC - PubMed
1. GBD 2016 Neurology Collaborators (2019) Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the global burden of Disease Study 2016. Lancet Neurol 18:459–480. 10.1016/S1474-4422(18)30499-X 10.1016/S1474-4422(18)30499-X - DOI - PMC - PubMed
1. GBD 2019 Dementia Forecasting Collaborators (2022) Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of Disease Study 2019. Lancet Public Health 7:e105–e125. 10.1016/S2468-2667(21)00249-8 10.1016/S2468-2667(21)00249-8 - DOI - PMC - PubMed
1. Migliore L, Coppedè F (2022) Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics. Nat Rev Neurol 18:643–660. 10.1038/s41582-022-00714-w 10.1038/s41582-022-00714-w - DOI - PubMed

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Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies

Affiliations

Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous