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. 2024 Aug 7:10.1097/INF.0000000000004515.
doi: 10.1097/INF.0000000000004515. Online ahead of print.

Sulfamethoxazole-Trimethoprim Prophylaxis in Pediatric Oncology Patients With Glucose-6-Phosphate Dehydrogenase Deficiency

Rachael M Stone  1 , Cyrine E Haidar  1 , Nancy M Kornegay  1 , Patricia J Barker  1 , Seth E Karol  2 , Joshua Wolf  3 , Jane S Hankins  4 , Mary V Relling  1 , Kristine R Crews  1
Affiliations

Sulfamethoxazole-Trimethoprim Prophylaxis in Pediatric Oncology Patients With Glucose-6-Phosphate Dehydrogenase Deficiency

Rachael M Stone et al. Pediatr Infect Dis J. .

Abstract

We sought to determine whether Pneumocystis jirovecii pneumonia prophylaxis with sulfamethoxazole-trimethoprim (SMX-TMP) is associated with an increased frequency of acute hemolytic anemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency versus non-G6PD-deficient controls in a pediatric oncology population. There was no statistically significant difference in change in hemoglobin or transfusion requirements after starting SMX-TMP between groups. These findings suggest no increased risk of acute hemolytic anemia with SMX-TMP administered at prophylaxis doses in patients with G6PD deficiency.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. Luzzatto L, & Arese P (2018). Favism and glucose-6-phosphate dehydrogenase deficiency. N Engl J Med, 378(1), 60–71. - PubMed
    1. Luzzatto L, Nannelli C, Notaro R. Glucose-6-Phosphate Dehydrogenase Deficiency. Hematol Oncol Clin North Am. 2016. Apr;30(2):373–93. - PubMed
    1. Morris SA, Crews KR, Hayden RT, Takemoto CM, Yang W, Baker DK, Broeckel U, Relling MV, Haidar CE. Incorporating G6PD genotyping to identify patients with G6PD deficiency. Pharmacogenet Genomics. 2022. Apr 1;32(3):87–93. - PMC - PubMed
    1. WHO. Meeting report of the technical consultation to review the classification of glucose-6-phosphate dehydrogenase (G6PD). https://www.who.int/publications/m/item/WHOUCN-GMP-MPAG-2022.01 (2022). Accessed June 9 2023.
    1. PharmGKB. (n.d.). Sulfamethoxazole/Trimethoprim Drug Label Annotations. PharmGKB. https://www.pharmgkb.org/chemical/PA10715/labelAnnotation. Accessed May 30 2023.

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