Fracture-related infection blood-based biomarkers: Diagnostic strategies
- PMID: 39164161
- DOI: 10.1016/j.injury.2024.111823
Fracture-related infection blood-based biomarkers: Diagnostic strategies
Abstract
Fracture-related infections are significant postoperative complications that carry substantial patient burden and additional healthcare costs. Despite their impact on outcome, early diagnosis of these infections remains challenging due to current available tests lacking acceptable diagnostic parameters. This review compiles existing information on blood-based biomarkers that have been evaluated as early diagnostic tools and highlights the challenges in their reliability. To begin to overcome these challenges new avenues of biomarker discovery utilizing "omics" technologies and novel analytical methods are being investigated in recent years. It appears that, despite their complexity, these newer approaches may be the future in biomarker discovery for fracture-related infection diagnosis.
Keywords: Biomarker; Fracture; Infection.
Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Roman M. Natoli and Sarah Malek have patent METHODS FOR DETECTING FRACTURE-RELATED INFECTION (FRI) pending to The Trustees of Indiana University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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