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. 2024 Aug 20;24(1):842.
doi: 10.1186/s12879-024-09621-5.

High myoglobin level as an independent risk factor for death in elderly patients with critical COVID-19 infection: a retrospective case-control study

Xiaoxiao Sun #  1   2 , Hui Zhang #  2 , Meixian Zhang  2 , Miaomiao Fei  2 , Lize Xiong  3 , Cheng Li  4
Affiliations

High myoglobin level as an independent risk factor for death in elderly patients with critical COVID-19 infection: a retrospective case-control study

Xiaoxiao Sun et al. BMC Infect Dis. .

Abstract

Aim: This study aimed to discover risk factors for death in patients with critical COVID-19 infection in order to identify patients with a higher risk of death at an early stage.

Methods: We retrospectively analyzed the clinical data of patients with critical COVID-19 infection from April 2022 to June 2022. Data were collected from the electronic medical records. Propensity matching scores were used to reduce the effect of confounding factors, such as patient baseline variables. Independent risk factors affecting patient prognosis were assessed using univariate logistic regression and multivariate logistic regression analysis. Restricted cubic spline curves were used to assess the relationship between independent and dependent variables.

Results: The data of 132 patients with critical COVID-19 infection were included in the study. Of the 132 patients, 79 survived and 53 died. Among laboratory indicators, patients who died had higher proportions of abnormalities in procalcitonin, aspartate aminotransferase (AST), creatinine, cardiac troponin I, and myoglobin. Univariate and multivariate logistic regression analyses suggested that abnormal AST (OR = 4.98, P = 0.02), creatinine (OR = 7.93, P = 0.021), and myoglobin (OR = 103.08, P = 0.002) were independent risk factors for death. After correction for AST and creatinine, a linear relationship between myoglobin and risk of death in patients was found using restricted cubic splines.

Conclusion: High myoglobin level is an independent risk factor for death and is therefore a prognostic marker in elderly patients with severe COVID-19 infection.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Logistic regression analysis. A: The outcome of univariate logistic regression analysis. B: The outcome of multivariate logistic regression analysis
Fig. 2
Fig. 2
Logistic regression analysis after PSM. A: The outcome of univariate logistic regression analysis after PSM. B: The outcome of multivariate logistic regression analysis after PSM
Fig. 3
Fig. 3
Relationship between myoglobin and dead risk
See this image and copyright information in PMC

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