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. 2024 Aug 20;24(1):2254.
doi: 10.1186/s12889-024-19740-y.

Public health management of invasive meningococcal disease outbreaks: worldwide 1973-2018, a systematic review

Brianna R Morello  1 , Adriana Milazzo  1 , Helen Siobhan Marshall  2   3   4 , Lynne C Giles  5   6
Affiliations

Public health management of invasive meningococcal disease outbreaks: worldwide 1973-2018, a systematic review

Brianna R Morello et al. BMC Public Health. .

Abstract

Background: Infectious disease outbreaks are an ongoing public health concern, requiring extensive resources to prevent and manage. Invasive Meningococcal Disease (IMD) is a severe outcome of infection with Neisseria meningitidis bacteria, which can be carried and transmitted asymptomatically. IMD is not completely vaccine-preventable, presenting an ongoing risk of outbreak development. This review provides a retrospective assessment of public health management of IMD outbreaks.

Methods: A systematic search was performed in PubMed and EMBASE. English-language studies reporting on IMD outbreaks and associated public health response were considered eligible. Reporting on key characteristics including outbreak size, duration, location, and public health response were assessed against Strengthening the Reporting of Observational studies in Epidemiology guidelines. A summary of lessons learned and author recommendations for each article were also discussed.

Results: 39 eligible studies were identified, describing 35 outbreaks in seven regions. Responses to outbreaks were mostly reactive, involving whole communities over prioritising those at highest risk of transmission. Recent responses identified a need for more proactive and targeted controls. Reporting was inconsistent, with key characteristics such as outbreak size, duration, or response absent or incompletely described.

Conclusion: There is a need for clear, comprehensive reporting on IMD outbreaks and their public health response to inform policy and practice for subsequent outbreaks of IMD and other infectious diseases.

Keywords: Communicable disease control; Disease outbreaks; Mass drug administration; Mass vaccination; Meningitis; Meningococcal; Meningococcal infections; Meningococcal vaccines; Public health.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA diagram of literature search and screening process. From: Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71. doi: 10.1136/bmj.n71. For more information, visit: http://www.prisma-statement.org/
Fig. 2
Fig. 2
Map of reported outbreak locations (n = 32) showing relative cumulative attack rates (number of cases per 100,000 population) as reported in Table 2, color-coded by serogroup
See this image and copyright information in PMC

References

    1. Pace D, Pollard AJ. Meningococcal disease: clinical presentation and sequelae. Vaccine. 2012;30(2):B3–9. Suppl 2(suppl. 10.1016/j.vaccine.2011.12.062 - DOI - PubMed
    1. Caugant DA, Tzanakaki G, Kriz P. Lessons from meningococcal carriage studies. FEMS Microbiol Rev. 2007;31(1):52–63. 10.1111/j.1574-6976.2006.00052.x - DOI - PubMed
    1. Peterson ME, Mile R, Li Y, Nair H, Kyaw MH. Meningococcal carriage in high-risk settings: a systematic review. Int J Infect Dis. 2018;73:109–17. 10.1016/j.ijid.2018.05.022 - DOI - PubMed
    1. Borrow R, Alarcon P, Carlos J, Caugant DA, Christensen H, Debbag R, et al. The Global Meningococcal Initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection. Expert rev vacc. 2017;16(4):313–28. 10.1080/14760584.2017.1258308 - DOI - PubMed
    1. Harrison LH, Pelton SI, Wilder-Smith A, Holst J, Safadi MAP, Vazquez JA, et al. The Global Meningococcal Initiative: recommendations for reducing the global burden of meningococcal disease. Vaccine. 2011;29(18):3363–71. 10.1016/j.vaccine.2011.02.058 - DOI - PubMed

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