Long-term effect of increasing water intake on repeated self-assessed health-related quality of life (HRQoL) in autosomal dominant polycystic kidney disease

Gopala Rangan^{1

2}, Margaret Allman-Farinelli³, Neil Boudville^{4

5}, Mangalee Fernando⁶, Imad Haloob⁷, David C H Harris^{1

2}, Carmel M Hawley^{8

9

10}, Karthik Kumar¹¹, David W Johnson^{8

9

10}, Vincent W Lee^{1

2}, Jun Mai¹², Anna Rangan³, Simon D Roger¹³, Priyanka Sagar¹⁴, Kamal Sud¹⁴, Vicente Torres¹⁵, Eswari Vilayur¹⁶

Affiliations

¹ Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
² Department of Renal Medicine, Westmead Hospital, Western Sydney Local Health District, Sydney, Australia.
³ School of Nursing, The University of Sydney, Sydney, NSW, Australia.
⁴ Sir Charles Gairdner Hospital, Perth, Australia.
⁵ Medical School, University of Western Australia, Perth, Australia.
⁶ Department of Renal Medicine, Prince of Wales Hospital, Sydney, NSW, Australia.
⁷ Department of Renal Medicine, Bathurst Hospital, Bathurst, Australia.
⁸ Australasian Kidney Trials Network, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia.
⁹ Translational Research Institute, Brisbane, Australia.
¹⁰ Department of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, Australia.
¹¹ Gosford Nephrology, Gosford, Australia.
¹² Department of Renal Medicine, Liverpool Hospital, Southwestern Sydney Local Health District, Sydney, NSW, Australia.
¹³ Renal Research, Gosford, Australia.
¹⁴ Nepean Kidney Research Centre, Department of Renal Medicine, Nepean Hospital and Nepean Clinical School, The University of Sydney, Sydney, Australia.
¹⁵ Translational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, USA.
¹⁶ Department of Nephrology, John Hunter Hospital, Newcastle, Australia.

PMID: 39165901
PMCID: PMC11333960
DOI: 10.1093/ckj/sfae159

Long-term effect of increasing water intake on repeated self-assessed health-related quality of life (HRQoL) in autosomal dominant polycystic kidney disease

Gopala Rangan et al. Clin Kidney J. 2024.

. 2024 Jun 7;17(7):sfae159.

doi: 10.1093/ckj/sfae159. eCollection 2024 Jul.

Authors

Affiliations

¹ Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, Australia.
² Department of Renal Medicine, Westmead Hospital, Western Sydney Local Health District, Sydney, Australia.
³ School of Nursing, The University of Sydney, Sydney, NSW, Australia.
⁴ Sir Charles Gairdner Hospital, Perth, Australia.
⁵ Medical School, University of Western Australia, Perth, Australia.
⁶ Department of Renal Medicine, Prince of Wales Hospital, Sydney, NSW, Australia.
⁷ Department of Renal Medicine, Bathurst Hospital, Bathurst, Australia.
⁸ Australasian Kidney Trials Network, University of Queensland at Princess Alexandra Hospital, Brisbane, Australia.
⁹ Translational Research Institute, Brisbane, Australia.
¹⁰ Department of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, Australia.
¹¹ Gosford Nephrology, Gosford, Australia.
¹² Department of Renal Medicine, Liverpool Hospital, Southwestern Sydney Local Health District, Sydney, NSW, Australia.
¹³ Renal Research, Gosford, Australia.
¹⁴ Nepean Kidney Research Centre, Department of Renal Medicine, Nepean Hospital and Nepean Clinical School, The University of Sydney, Sydney, Australia.
¹⁵ Translational Polycystic Kidney Disease Center, Mayo Clinic, Rochester, USA.
¹⁶ Department of Nephrology, John Hunter Hospital, Newcastle, Australia.

PMID: 39165901
PMCID: PMC11333960
DOI: 10.1093/ckj/sfae159

Abstract

Background: The aim of this study was to determine the long-term effect of increasing water intake in patients with autosomal dominant polycystic kidney disease (ADPKD) on longitudinal changes in health-related quality of life (HRQoL) in the setting of a clinical trial.

Methods: Self-completed HRQoL (using the KDQoL-SF, v.1.3 questionnaire) was assessed annually in participants of a 3-year randomized controlled clinical trial (n = 187), allocated (1:1) either to increase water intake to reduce urine osmolality to ≤270 mosmol/kg (implemented by dietetic coaching, self-monitoring tools, text messaging) or continue usual water intake.

Results: Overall, 96% and 81.8% of participants (n = 187) completed the questionnaire at the baseline and final study visits, respectively. At baseline, the physical component summary score (PCS) and mental component summary score (MCS) were similar in the two groups (P > 0.05) and the five dimensions with the lowest scores in both groups were: energy and fatigue; general and overall health; sleep; emotional well-being; and pain. Within each group, there were no longitudinal changes over time. At the final visit, the PCS was higher in the increased water intake group (51.3 ± 7.6, mean ± standard deviation) compared to the usual water intake group 48.8 ± 9.3; P = 0.037) whereas the MCS was numerically similar. The improvement in the PCS was due to higher sub-scale values for physical functioning and pain (both P < 0.05). By multivariate analysis, only baseline PCS and height-corrected total kidney volume were associated with the final PCS (P < 0.05).

Conclusion: HRQoL scores remained stable over a 3 year period, and were not adversely affected by the intervention to increase water intake. Future studies should evaluate the clinical significance of the higher PCS in the increased water intake group.

Keywords: ADPKD; CKD; clinical trial; polycystic kidney disease; quality of life.

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Conflict of interest statement

G.R. reports research grants and travel sponsorship from Danone Research, Otsuka, and Sanofi. D.W.J. has received consultancy fees, research grants, speaker's honoraria, and travel sponsorships from Baxter Healthcare and Fresenius Medical Care, consultancy fees from Astra Zeneca, Bayer, and AWAK, speaker's honoraria from ONO and Boehringer Ingelheim & Lilly, and travel sponsorships from ONO and Amgen.

References

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Long-term effect of increasing water intake on repeated self-assessed health-related quality of life (HRQoL) in autosomal dominant polycystic kidney disease

Affiliations

Long-term effect of increasing water intake on repeated self-assessed health-related quality of life (HRQoL) in autosomal dominant polycystic kidney disease

Authors

Affiliations

Abstract

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources